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- NCIT_C127124 IAO_0000115 "A human monoclonal antibody against the protein V-domain immunoglobulin (Ig) suppressor of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential negative checkpoint regulatory and antineoplastic activities. Upon administration, onvatilimab targets and binds to VISTA. This inhibits VISTA signaling, abrogates the VISTA-induced suppression of T-lymphocyte-mediated immune responses, enhances cytotoxic T-cell responses against tumor cells and inhibits tumor cell growth. VISTA, mainly expressed on hematopoietic cells, plays a key role in immunosuppression." @default.
- NCIT_C127124 NCIT_A32 NCIT_C1909 @default.
- NCIT_C127124 NCIT_A7 NCIT_C120581 @default.
- NCIT_C127124 NCIT_NHC0 "C127124" @default.
- NCIT_C127124 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C127124 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C127124 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C127124 NCIT_P107 "Onvatilimab" @default.
- NCIT_C127124 NCIT_P108 "Onvatilimab" @default.
- NCIT_C127124 NCIT_P208 "CL507914" @default.
- NCIT_C127124 NCIT_P210 "1969313-51-6" @default.
- NCIT_C127124 NCIT_P319 "1UI8F5IIZ4" @default.
- NCIT_C127124 NCIT_P322 "CTRP" @default.
- NCIT_C127124 NCIT_P322 "FDA" @default.
- NCIT_C127124 NCIT_P322 "GDC" @default.
- NCIT_C127124 NCIT_P375 "Anti-VISTA Monoclonal Antibody JNJ 61610588" @default.
- NCIT_C127124 NCIT_P375 "Onvatilimab" @default.
- NCIT_C127124 NCIT_P399 "780996" @default.
- NCIT_C127124 NCIT_R124 NCIT_C17710 @default.
- NCIT_C127124 NCIT_R124 NCIT_C17828 @default.
- NCIT_C127124 NCIT_R124 NCIT_C18219 @default.
- NCIT_C127124 NCIT_R124 NCIT_C19986 @default.
- NCIT_C127124 NCIT_R124 NCIT_C40474 @default.
- NCIT_C127124 normalizedInformationContent "100" @default.
- NCIT_C127124 referenceCount "1" @default.
- NCIT_C127124 hasExactSynonym "CI 8993" @default.
- NCIT_C127124 hasExactSynonym "CI-8993" @default.
- NCIT_C127124 hasExactSynonym "CI8993" @default.
- NCIT_C127124 hasExactSynonym "Immunoglobulin G1, Anti-(Human Protein Vista (v-domain Immunoglobulin Suppressor of T Cell Activation)) (Human Clone JNJ 61610588 gamma1-chain), Disulfide with Human Clone JNJ" @default.
- NCIT_C127124 hasExactSynonym "JNJ 61610588" @default.
- NCIT_C127124 hasExactSynonym "JNJ-61610588" @default.
- NCIT_C127124 hasExactSynonym "ONVATILIMAB" @default.
- NCIT_C127124 hasExactSynonym "Onvatilimab" @default.
- NCIT_C127124 hasExactSynonym "WHO 10758" @default.
- NCIT_C127124 inSubset NCIT_C116977 @default.
- NCIT_C127124 inSubset NCIT_C116978 @default.
- NCIT_C127124 inSubset NCIT_C128784 @default.
- NCIT_C127124 inSubset NCIT_C157711 @default.
- NCIT_C127124 inSubset NCIT_C157712 @default.
- NCIT_C127124 inSubset NCIT_C176424 @default.
- NCIT_C127124 inSubset NCIT_C177537 @default.
- NCIT_C127124 inSubset NCIT_C63923 @default.
- NCIT_C127124 type Class @default.
- NCIT_C127124 isDefinedBy ncit.owl @default.
- NCIT_C127124 label "Onvatilimab" @default.
- NCIT_C127124 subClassOf NCIT_C127124 @default.
- NCIT_C127124 subClassOf NCIT_C129821 @default.
- NCIT_C127124 subClassOf NCIT_C129822 @default.
- NCIT_C127124 subClassOf NCIT_C141144 @default.
- NCIT_C127124 subClassOf NCIT_C143250 @default.
- NCIT_C127124 subClassOf NCIT_C163758 @default.
- NCIT_C127124 subClassOf NCIT_C1908 @default.
- NCIT_C127124 subClassOf NCIT_C1909 @default.
- NCIT_C127124 subClassOf NCIT_C199655 @default.
- NCIT_C127124 subClassOf NCIT_C199656 @default.
- NCIT_C127124 subClassOf NCIT_C20401 @default.
- NCIT_C127124 subClassOf NCIT_C274 @default.
- NCIT_C127124 subClassOf NCIT_C307 @default.
- NCIT_C127124 subClassOf NCIT_C308 @default.