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- NCIT_C127817 IAO_0000115 "An inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. Upon administration, tapotoclax binds to and inhibits the activity of MCL-1. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival." @default.
- NCIT_C127817 NCIT_A32 NCIT_C1909 @default.
- NCIT_C127817 NCIT_A7 NCIT_C17688 @default.
- NCIT_C127817 NCIT_NHC0 "C127817" @default.
- NCIT_C127817 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C127817 NCIT_P107 "Tapotoclax" @default.
- NCIT_C127817 NCIT_P108 "Tapotoclax" @default.
- NCIT_C127817 NCIT_P208 "CL507931" @default.
- NCIT_C127817 NCIT_P210 "1883727-34-1" @default.
- NCIT_C127817 NCIT_P319 "97W7N9T08G" @default.
- NCIT_C127817 NCIT_P322 "CTRP" @default.
- NCIT_C127817 NCIT_P322 "FDA" @default.
- NCIT_C127817 NCIT_P322 "GDC" @default.
- NCIT_C127817 NCIT_P329 "781850" @default.
- NCIT_C127817 NCIT_P330 "781850" @default.
- NCIT_C127817 NCIT_P375 "MCL-1 Inhibitor AMG 176" @default.
- NCIT_C127817 NCIT_P375 "Tapotoclax" @default.
- NCIT_C127817 NCIT_P399 "781850" @default.
- NCIT_C127817 normalizedInformationContent "100" @default.
- NCIT_C127817 referenceCount "1" @default.
- NCIT_C127817 hasExactSynonym "AMG 176" @default.
- NCIT_C127817 hasExactSynonym "TAPOTOCLAX" @default.
- NCIT_C127817 hasExactSynonym "Tapotoclax" @default.
- NCIT_C127817 inSubset NCIT_C116977 @default.
- NCIT_C127817 inSubset NCIT_C116978 @default.
- NCIT_C127817 inSubset NCIT_C128784 @default.
- NCIT_C127817 inSubset NCIT_C157711 @default.
- NCIT_C127817 inSubset NCIT_C157712 @default.
- NCIT_C127817 inSubset NCIT_C176424 @default.
- NCIT_C127817 inSubset NCIT_C177537 @default.
- NCIT_C127817 inSubset NCIT_C63923 @default.
- NCIT_C127817 type Class @default.
- NCIT_C127817 isDefinedBy ncit.owl @default.
- NCIT_C127817 label "Tapotoclax" @default.
- NCIT_C127817 subClassOf NCIT_C127817 @default.
- NCIT_C127817 subClassOf NCIT_C129839 @default.
- NCIT_C127817 subClassOf NCIT_C137990 @default.
- NCIT_C127817 subClassOf NCIT_C1908 @default.
- NCIT_C127817 subClassOf NCIT_C1909 @default.
- NCIT_C127817 subClassOf NCIT_C192025 @default.
- NCIT_C127817 subClassOf NCIT_C274 @default.