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- NCIT_C127839 IAO_0000115 "A proprietary formulation containing a highly purified form of Staphylococcal protein A (SpA; protein A), with potential immunomodulating activity. Upon administration of bevifimod, this protein is able to specifically bind to both the subset of B-lymphocytes that express the heavy chain variable region 3 (VH3)-encoded immunoglobulin (Ig) (VH3-B-cells) and macrophages. This prevents B-cell activation, induces apoptosis, prevents VH3-derived antibody formation, antibody-mediated immune responses, and destruction by macrophages. This may modulate specific immune signaling pathways and restore normal immune system functions caused by certain immune-mediated inflammatory diseases. In patients with the autoimmune-mediated disease immune thrombocytopenia (ITP), PRTX-100 prevents destruction of platelets, increases platelet production and platelet blood levels, and decreases the risk of bleeding. SpA, a 42 kDa bacterial membrane protein produced by Staphylococcus aureus bacteria, consists of five nearly identical Ig binding domains; each SpA domain binds with high affinity to the Igs containing regions encoded by the VH3 gene family. B-lymphocytes that express VH3-encoded Igs are specifically involved in various auto-immune diseases." @default.
- NCIT_C127839 NCIT_NHC0 "C127839" @default.
- NCIT_C127839 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C127839 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C127839 NCIT_P107 "Bevifimod" @default.
- NCIT_C127839 NCIT_P108 "Bevifimod" @default.
- NCIT_C127839 NCIT_P208 "CL507917" @default.
- NCIT_C127839 NCIT_P210 "2223113-32-2" @default.
- NCIT_C127839 NCIT_P319 "PNV0H3A73B" @default.
- NCIT_C127839 NCIT_P322 "CTRP" @default.
- NCIT_C127839 NCIT_P322 "FDA" @default.
- NCIT_C127839 NCIT_P329 "781146" @default.
- NCIT_C127839 NCIT_P330 "781146" @default.
- NCIT_C127839 NCIT_P399 "781146" @default.
- NCIT_C127839 normalizedInformationContent "100" @default.
- NCIT_C127839 referenceCount "1" @default.
- NCIT_C127839 hasExactSynonym "BEVIFIMOD" @default.
- NCIT_C127839 hasExactSynonym "Bevifimod" @default.
- NCIT_C127839 hasExactSynonym "Highly Purified Staphylococcal Protein A PRTX-100" @default.
- NCIT_C127839 hasExactSynonym "PRTX-100" @default.
- NCIT_C127839 hasExactSynonym "SpA PRTX-100" @default.
- NCIT_C127839 inSubset NCIT_C116977 @default.
- NCIT_C127839 inSubset NCIT_C116978 @default.
- NCIT_C127839 inSubset NCIT_C176424 @default.
- NCIT_C127839 inSubset NCIT_C63923 @default.
- NCIT_C127839 type Class @default.
- NCIT_C127839 isDefinedBy ncit.owl @default.
- NCIT_C127839 label "Bevifimod" @default.
- NCIT_C127839 subClassOf NCIT_C127839 @default.
- NCIT_C127839 subClassOf NCIT_C1908 @default.
- NCIT_C127839 subClassOf NCIT_C1909 @default.
- NCIT_C127839 subClassOf NCIT_C308 @default.