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- NCIT_C127900 IAO_0000115 "An indenoisoquinoline derivative and topoisomerase 1 (Top1) inhibitor, with potential antineoplastic activity. Upon administration, LMP744 binds to and stabilizes cleaved DNA-Top1 complexes, which prevents DNA re-ligation, induces stable, irreversible DNA strand breaks, prevents DNA repair, and leads to cell cycle arrest and apoptosis. As tumor cells proliferate at a much higher rate than normal cells, LMP744 specifically targets cancer cells. Top1, a DNA modifying enzyme essential for transcription, replication, and repair of double-strand DNA breaks, is overexpressed in tumor cells." @default.
- NCIT_C127900 NCIT_A32 NCIT_C1909 @default.
- NCIT_C127900 NCIT_A7 NCIT_C16516 @default.
- NCIT_C127900 NCIT_NHC0 "C127900" @default.
- NCIT_C127900 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C127900 NCIT_P107 "Topoisomerase-1 Inhibitor LMP744" @default.
- NCIT_C127900 NCIT_P108 "Topoisomerase-1 Inhibitor LMP744" @default.
- NCIT_C127900 NCIT_P208 "CL509262" @default.
- NCIT_C127900 NCIT_P210 "308246-52-8" @default.
- NCIT_C127900 NCIT_P319 "29BY7HQV0T" @default.
- NCIT_C127900 NCIT_P322 "CTRP" @default.
- NCIT_C127900 NCIT_P322 "FDA" @default.
- NCIT_C127900 NCIT_P322 "GDC" @default.
- NCIT_C127900 NCIT_P329 "787756" @default.
- NCIT_C127900 NCIT_P330 "787756" @default.
- NCIT_C127900 NCIT_P375 "Topoisomerase-1 Inhibitor LMP744" @default.
- NCIT_C127900 NCIT_P399 "787756" @default.
- NCIT_C127900 normalizedInformationContent "100" @default.
- NCIT_C127900 referenceCount "1" @default.
- NCIT_C127900 hasExactSynonym "5H-(1,3)Dioxolo(5,6)indeno(1,2-C)isoquinoline-5,12(6H)-dione, 6-(3-((2-Hydroxyethyl)amino)propyl)-2,3-dimethoxy-" @default.
- NCIT_C127900 hasExactSynonym "Indenoisoquinoline LMP744" @default.
- NCIT_C127900 hasExactSynonym "LMP-744" @default.
- NCIT_C127900 hasExactSynonym "LMP744" @default.
- NCIT_C127900 hasExactSynonym "Topoisomerase-1 Inhibitor LMP744" @default.
- NCIT_C127900 inSubset NCIT_C116977 @default.
- NCIT_C127900 inSubset NCIT_C116978 @default.
- NCIT_C127900 inSubset NCIT_C128784 @default.
- NCIT_C127900 inSubset NCIT_C157711 @default.
- NCIT_C127900 inSubset NCIT_C157712 @default.
- NCIT_C127900 inSubset NCIT_C176424 @default.
- NCIT_C127900 inSubset NCIT_C177537 @default.
- NCIT_C127900 inSubset NCIT_C63923 @default.
- NCIT_C127900 type Class @default.
- NCIT_C127900 isDefinedBy ncit.owl @default.
- NCIT_C127900 label "Topoisomerase-1 Inhibitor LMP744" @default.
- NCIT_C127900 subClassOf NCIT_C127900 @default.
- NCIT_C127900 subClassOf NCIT_C129824 @default.
- NCIT_C127900 subClassOf NCIT_C129825 @default.
- NCIT_C127900 subClassOf NCIT_C1748 @default.
- NCIT_C127900 subClassOf NCIT_C1904 @default.
- NCIT_C127900 subClassOf NCIT_C1908 @default.
- NCIT_C127900 subClassOf NCIT_C1909 @default.
- NCIT_C127900 subClassOf NCIT_C2189 @default.
- NCIT_C127900 subClassOf NCIT_C274 @default.
- NCIT_C127900 subClassOf NCIT_C471 @default.