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- NCIT_C127906 IAO_0000115 "A mixture of two humanized immunoglobulin G1 (IgG1) monoclonal antibodies, Hu9006 and Hu9338, which recognize non-overlapping epitopes in the extracellular domain of the human hepatocyte growth factor receptor (MET; HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-MET monoclonal antibody mixture Sym015 targets and binds to the extracellular domain of MET, thereby preventing the binding of its ligand, hepatocyte growth factor (HGF). This may prevent activation of the receptor and MET-mediated signal transduction pathways. This inhibits MET-dependent tumor cell proliferation. MET, a receptor tyrosine kinase, is overexpressed on the cell surfaces of various solid tumor cell types; it plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis." @default.
- NCIT_C127906 NCIT_A32 NCIT_C1909 @default.
- NCIT_C127906 NCIT_A7 NCIT_C18186 @default.
- NCIT_C127906 NCIT_NHC0 "C127906" @default.
- NCIT_C127906 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C127906 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C127906 NCIT_P107 "Anti-Met Monoclonal Antibody Mixture Sym015" @default.
- NCIT_C127906 NCIT_P108 "Anti-Met Monoclonal Antibody Mixture Sym015" @default.
- NCIT_C127906 NCIT_P208 "CL507929" @default.
- NCIT_C127906 NCIT_P322 "CTRP" @default.
- NCIT_C127906 NCIT_P322 "GDC" @default.
- NCIT_C127906 NCIT_P329 "781406" @default.
- NCIT_C127906 NCIT_P330 "781406" @default.
- NCIT_C127906 NCIT_P375 "Anti-Met Monoclonal Antibody Mixture Sym015" @default.
- NCIT_C127906 NCIT_P399 "781406" @default.
- NCIT_C127906 NCIT_R124 NCIT_C17710 @default.
- NCIT_C127906 NCIT_R124 NCIT_C17828 @default.
- NCIT_C127906 NCIT_R124 NCIT_C18219 @default.
- NCIT_C127906 NCIT_R124 NCIT_C19986 @default.
- NCIT_C127906 NCIT_R124 NCIT_C40474 @default.
- NCIT_C127906 normalizedInformationContent "100" @default.
- NCIT_C127906 referenceCount "1" @default.
- NCIT_C127906 hasExactSynonym "Anti-Met Monoclonal Antibody Mixture Sym015" @default.
- NCIT_C127906 hasExactSynonym "Hu9006-Hu9338" @default.
- NCIT_C127906 hasExactSynonym "Hu9006/Hu9338" @default.
- NCIT_C127906 hasExactSynonym "Sym 015" @default.
- NCIT_C127906 hasExactSynonym "Sym-015" @default.
- NCIT_C127906 hasExactSynonym "Sym015" @default.
- NCIT_C127906 inSubset NCIT_C116977 @default.
- NCIT_C127906 inSubset NCIT_C116978 @default.
- NCIT_C127906 inSubset NCIT_C128784 @default.
- NCIT_C127906 inSubset NCIT_C157711 @default.
- NCIT_C127906 inSubset NCIT_C157712 @default.
- NCIT_C127906 inSubset NCIT_C176424 @default.
- NCIT_C127906 inSubset NCIT_C177537 @default.
- NCIT_C127906 type Class @default.
- NCIT_C127906 isDefinedBy ncit.owl @default.
- NCIT_C127906 label "Anti-Met Monoclonal Antibody Mixture Sym015" @default.
- NCIT_C127906 subClassOf NCIT_C127906 @default.
- NCIT_C127906 subClassOf NCIT_C129821 @default.
- NCIT_C127906 subClassOf NCIT_C129822 @default.
- NCIT_C127906 subClassOf NCIT_C1908 @default.
- NCIT_C127906 subClassOf NCIT_C1909 @default.
- NCIT_C127906 subClassOf NCIT_C20401 @default.
- NCIT_C127906 subClassOf NCIT_C274 @default.
- NCIT_C127906 subClassOf NCIT_C307 @default.
- NCIT_C127906 subClassOf NCIT_C308 @default.