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- NCIT_C127910 IAO_0000115 "A polyepitope plasmid DNA vaccine containing the mammalian expression vector pUMVC3 encoding epitopes derived from three tumor-associated antigens (TAAs): human insulin-like growth factor-binding protein 2 (IGFBP2), human epidermal growth factor receptor 2 (HER2; ERBB2) and insulin-like growth factor 1 receptor (IGF1R), with potential immunostimulating and antineoplastic activities. Upon intradermal vaccination, pUMVC3-IGFBP2-HER2-IGF1R plasmid DNA vaccine transfects local keratinocytes, which process the plasmid, express the epitopes and present them to antigen-presenting cells (APCs). This activates the immune system to mount a combined response from specific T helper type 1 (Th1) cells, memory T-cells and cytotoxic T-lymphocytes (CTL) against IGFBP2-, HER2-, and IGF1R-expressing tumor cells. IGFBP2, HER2, and IGF1R are tumor-associated proteins overexpressed in certain tumor cell types, and play key roles in cellular proliferation and survival." @default.
- NCIT_C127910 NCIT_A7 NCIT_C17319 @default.
- NCIT_C127910 NCIT_A7 NCIT_C17506 @default.
- NCIT_C127910 NCIT_A7 NCIT_C17531 @default.
- NCIT_C127910 NCIT_NHC0 "C127910" @default.
- NCIT_C127910 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C127910 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C127910 NCIT_P107 "pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine" @default.
- NCIT_C127910 NCIT_P108 "pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine" @default.
- NCIT_C127910 NCIT_P208 "CL507933" @default.
- NCIT_C127910 NCIT_P322 "CTRP" @default.
- NCIT_C127910 NCIT_P329 "781920" @default.
- NCIT_C127910 NCIT_P330 "781920" @default.
- NCIT_C127910 NCIT_P399 "781920" @default.
- NCIT_C127910 normalizedInformationContent "100" @default.
- NCIT_C127910 referenceCount "1" @default.
- NCIT_C127910 hasExactSynonym "WOKVAC Vaccine" @default.
- NCIT_C127910 hasExactSynonym "WOKVAC" @default.
- NCIT_C127910 hasExactSynonym "pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine" @default.
- NCIT_C127910 hasExactSynonym "pUMVC3-IGFBP2-HER2-IGF1R Vaccine" @default.
- NCIT_C127910 hasExactSynonym "pUMVC3-IGFBP2-HER2-IGF1R" @default.
- NCIT_C127910 inSubset NCIT_C116977 @default.
- NCIT_C127910 inSubset NCIT_C116978 @default.
- NCIT_C127910 inSubset NCIT_C128784 @default.
- NCIT_C127910 inSubset NCIT_C176424 @default.
- NCIT_C127910 type Class @default.
- NCIT_C127910 isDefinedBy ncit.owl @default.
- NCIT_C127910 label "pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine" @default.
- NCIT_C127910 subClassOf NCIT_C127910 @default.
- NCIT_C127910 subClassOf NCIT_C1908 @default.
- NCIT_C127910 subClassOf NCIT_C1909 @default.
- NCIT_C127910 subClassOf NCIT_C307 @default.
- NCIT_C127910 subClassOf NCIT_C308 @default.
- NCIT_C127910 subClassOf NCIT_C39619 @default.
- NCIT_C127910 subClassOf NCIT_C923 @default.