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- NCIT_C127934 IAO_0000115 "A microparticle combining two immune-modifying components derived from the bacterium Propionibacterium acnes, a bacterial cell wall component that is rich in muramyl dipeptide (MDP) and single-stranded bacteria-derived DNA fragments, with potential immunomodulating and immunoadjuvant activities. Upon administration of MIS416, this agent localizes in and is taken up mainly by the liver, thereby forming a liver depot. MIS416 is then taken up by immune cells, such as monocytes and dendritic cells (DCs), where MDP and the bacterial DNA target and bind to the cytosolic innate pattern recognition receptors (PRRs) nucleotide-binding oligomerization domain-containing protein 2 (NOD2), and toll-like receptor 9 (TLR9), respectively. The simultaneous binding and activation of both NOD2 and TLR9, leads to activation of both NOD2 and TLR9 signaling. This stimulates the innate immune system, induces secretion of cytokines, particularly interferon (IFN), and modulates the activation of various immune cells. In the presence of tumor-associated antigens (TAAs), through simultaneous administration of a TAA-based vaccine, MIS416 modulates T-cell subsets and enhances the cytotoxic T lymphocyte (CTL)-mediated immune response against TAAs, resulting in an increased anti-tumor immune response. The combination of NOD2 and TLR9 agonists in MIS416 appears to activate different signaling pathways as compared to the administration of NOD2 and TLR9 agonists alone." @default.
- NCIT_C127934 NCIT_A7 NCIT_C74449 @default.
- NCIT_C127934 NCIT_A7 NCIT_C96048 @default.
- NCIT_C127934 NCIT_NHC0 "C127934" @default.
- NCIT_C127934 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C127934 NCIT_P107 "Microparticle MDP/Bacterial DNA-containing MIS416" @default.
- NCIT_C127934 NCIT_P108 "Microparticle MDP/Bacterial DNA-containing MIS416" @default.
- NCIT_C127934 NCIT_P208 "CL509275" @default.
- NCIT_C127934 NCIT_P322 "CTRP" @default.
- NCIT_C127934 normalizedInformationContent "100" @default.
- NCIT_C127934 referenceCount "1" @default.
- NCIT_C127934 hasExactSynonym "MIS 416" @default.
- NCIT_C127934 hasExactSynonym "MIS-416" @default.
- NCIT_C127934 hasExactSynonym "MIS416" @default.
- NCIT_C127934 hasExactSynonym "Microparticle MDP/Bacterial DNA-containing MIS416" @default.
- NCIT_C127934 hasExactSynonym "Microparticle MIS416" @default.
- NCIT_C127934 inSubset NCIT_C116977 @default.
- NCIT_C127934 inSubset NCIT_C116978 @default.
- NCIT_C127934 type Class @default.
- NCIT_C127934 isDefinedBy ncit.owl @default.
- NCIT_C127934 label "Microparticle MDP/Bacterial DNA-containing MIS416" @default.
- NCIT_C127934 subClassOf NCIT_C127934 @default.
- NCIT_C127934 subClassOf NCIT_C1908 @default.
- NCIT_C127934 subClassOf NCIT_C1909 @default.
- NCIT_C127934 subClassOf NCIT_C308 @default.