Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C128030> ?p ?o ?g. }
Showing items 1 to 40 of
40
with 100 items per page.
- NCIT_C128030 IAO_0000115 "A synthetic copolymer-drug conjugate of a fumagillin-derived methionine aminopeptidase 2 (MetAP2) inhibitor conjugated to the bio-compatible polymer poly(N-(hydroxypropyl)methacrylamide) (HPMA), with potential antineoplastic activity. Upon administration of SDX-7320, the active moiety SDX7539 is released inside the tumor cells. SDX7539 binds to and inhibits MetAP2, which prevents MetAP2-mediated signal transduction pathways and results in tumor cell death. MetAP2, a member of the dimetallohydrolase family upregulated in certain tumor cell types, plays a key role in angiogenesis, proliferation and survival. Polymer conjugation reduces systemic drug exposure and increases this agent's efficacy as compared to non-polymer conjugates." @default.
- NCIT_C128030 NCIT_A32 NCIT_C1909 @default.
- NCIT_C128030 NCIT_A7 NCIT_C143021 @default.
- NCIT_C128030 NCIT_NHC0 "C128030" @default.
- NCIT_C128030 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128030 NCIT_P107 "Evexomostat" @default.
- NCIT_C128030 NCIT_P108 "Evexomostat" @default.
- NCIT_C128030 NCIT_P208 "CL507924" @default.
- NCIT_C128030 NCIT_P210 "2416263-67-5" @default.
- NCIT_C128030 NCIT_P319 "Z7116W3IFA" @default.
- NCIT_C128030 NCIT_P322 "CTRP" @default.
- NCIT_C128030 NCIT_P322 "FDA" @default.
- NCIT_C128030 NCIT_P322 "GDC" @default.
- NCIT_C128030 NCIT_P329 "781275" @default.
- NCIT_C128030 NCIT_P330 "781275" @default.
- NCIT_C128030 NCIT_P375 "MetAP2 Inhibitor SDX-7320" @default.
- NCIT_C128030 NCIT_P399 "781275" @default.
- NCIT_C128030 normalizedInformationContent "100" @default.
- NCIT_C128030 referenceCount "1" @default.
- NCIT_C128030 hasExactSynonym "EVEXOMOSTAT" @default.
- NCIT_C128030 hasExactSynonym "Evexomostat" @default.
- NCIT_C128030 hasExactSynonym "MetAP2 Inhibitor SDX-7320" @default.
- NCIT_C128030 hasExactSynonym "Methionine aminopeptidase type II Inhibitor SDX-7320" @default.
- NCIT_C128030 hasExactSynonym "SDX-7320" @default.
- NCIT_C128030 inSubset NCIT_C116977 @default.
- NCIT_C128030 inSubset NCIT_C116978 @default.
- NCIT_C128030 inSubset NCIT_C128784 @default.
- NCIT_C128030 inSubset NCIT_C157711 @default.
- NCIT_C128030 inSubset NCIT_C157712 @default.
- NCIT_C128030 inSubset NCIT_C176424 @default.
- NCIT_C128030 inSubset NCIT_C177537 @default.
- NCIT_C128030 inSubset NCIT_C63923 @default.
- NCIT_C128030 type Class @default.
- NCIT_C128030 isDefinedBy ncit.owl @default.
- NCIT_C128030 label "Evexomostat" @default.
- NCIT_C128030 subClassOf NCIT_C128030 @default.
- NCIT_C128030 subClassOf NCIT_C1908 @default.
- NCIT_C128030 subClassOf NCIT_C1909 @default.
- NCIT_C128030 subClassOf NCIT_C471 @default.
- NCIT_C128030 subClassOf NCIT_C783 @default.