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- NCIT_C128250 IAO_0000115 "An orally bioavailable pan inhibitor of the serine/threonine protein kinase AKT (protein kinase B) enzyme family with potential antineoplastic activity. Upon oral administration, AKT inhibitor ARQ 751 selectively binds to and inhibits the activity of the AKT isoforms 1, 2 and 3, which may result in the inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. This may lead to a reduction in tumor cell proliferation and the induction of tumor cell apoptosis. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration." @default.
- NCIT_C128250 NCIT_A32 NCIT_C1909 @default.
- NCIT_C128250 NCIT_A7 NCIT_C41625 @default.
- NCIT_C128250 NCIT_NHC0 "C128250" @default.
- NCIT_C128250 NCIT_P106 "Organic Chemical" @default.
- NCIT_C128250 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128250 NCIT_P107 "Pan-AKT Inhibitor ARQ751" @default.
- NCIT_C128250 NCIT_P108 "Pan-AKT Inhibitor ARQ751" @default.
- NCIT_C128250 NCIT_P208 "CL507932" @default.
- NCIT_C128250 NCIT_P322 "CTRP" @default.
- NCIT_C128250 NCIT_P322 "GDC" @default.
- NCIT_C128250 NCIT_P329 "781919" @default.
- NCIT_C128250 NCIT_P330 "781919" @default.
- NCIT_C128250 NCIT_P375 "Pan-AKT Inhibitor ARQ751" @default.
- NCIT_C128250 NCIT_P399 "781919" @default.
- NCIT_C128250 normalizedInformationContent "100" @default.
- NCIT_C128250 referenceCount "1" @default.
- NCIT_C128250 hasExactSynonym "AKT Inhibitor ARQ751" @default.
- NCIT_C128250 hasExactSynonym "ARQ 751" @default.
- NCIT_C128250 hasExactSynonym "ARQ751" @default.
- NCIT_C128250 hasExactSynonym "Pan-AKT Inhibitor ARQ751" @default.
- NCIT_C128250 inSubset NCIT_C116977 @default.
- NCIT_C128250 inSubset NCIT_C116978 @default.
- NCIT_C128250 inSubset NCIT_C128784 @default.
- NCIT_C128250 inSubset NCIT_C157711 @default.
- NCIT_C128250 inSubset NCIT_C157712 @default.
- NCIT_C128250 inSubset NCIT_C176424 @default.
- NCIT_C128250 inSubset NCIT_C177537 @default.
- NCIT_C128250 type Class @default.
- NCIT_C128250 isDefinedBy ncit.owl @default.
- NCIT_C128250 label "Pan-AKT Inhibitor ARQ751" @default.
- NCIT_C128250 subClassOf NCIT_C128250 @default.
- NCIT_C128250 subClassOf NCIT_C129824 @default.
- NCIT_C128250 subClassOf NCIT_C129825 @default.
- NCIT_C128250 subClassOf NCIT_C1404 @default.
- NCIT_C128250 subClassOf NCIT_C155764 @default.
- NCIT_C128250 subClassOf NCIT_C1742 @default.
- NCIT_C128250 subClassOf NCIT_C1908 @default.
- NCIT_C128250 subClassOf NCIT_C1909 @default.
- NCIT_C128250 subClassOf NCIT_C2189 @default.
- NCIT_C128250 subClassOf NCIT_C274 @default.
- NCIT_C128250 subClassOf NCIT_C471 @default.
- NCIT_C128250 subClassOf NCIT_C61074 @default.