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- NCIT_C128281 IAO_0000115 "A population of engineered autologous T-lymphocytes in which the gene encoding for the programmed cell death protein 1 (PDCD-1) is deleted, with potential immunomodulating activity. Following collection of peripheral blood lymphocytes and selection of T-cells, the PDCD-1 gene was knocked out and the T-cells were expanded. Upon reinfusion of the PDCD-1 knockout T-lymphocytes, these T-cells target and lyse cancer cells. The PDCD-1 protein, found on activated T-cells and often overexpressed on T-cells in cancer patients, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. PDCD-1 knockout enhances cytotoxicity and T-cell-mediated anti-tumor immune responses." @default.
- NCIT_C128281 NCIT_NHC0 "C128281" @default.
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- NCIT_C128281 NCIT_P108 "PDCD-1 Knockout Autologous T-lymphocytes" @default.
- NCIT_C128281 NCIT_P208 "CL507935" @default.
- NCIT_C128281 NCIT_P329 "782061" @default.
- NCIT_C128281 NCIT_P330 "782061" @default.
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- NCIT_C128281 hasExactSynonym "PD-1 Knockout Autologous T-cells" @default.
- NCIT_C128281 hasExactSynonym "PD-1-disrupted Autologous T-lymphocytes" @default.
- NCIT_C128281 hasExactSynonym "PDCD-1 Knockout Autologous T Lymphocytes" @default.
- NCIT_C128281 hasExactSynonym "PDCD-1 Knockout Autologous T-lymphocytes" @default.
- NCIT_C128281 hasExactSynonym "PDCD1 Gene Knockout Autologous T-cells" @default.
- NCIT_C128281 inSubset NCIT_C128784 @default.
- NCIT_C128281 inSubset NCIT_C176424 @default.
- NCIT_C128281 type Class @default.
- NCIT_C128281 isDefinedBy ncit.owl @default.
- NCIT_C128281 label "PDCD-1 Knockout Autologous T-lymphocytes" @default.
- NCIT_C128281 subClassOf NCIT_C128281 @default.
- NCIT_C128281 subClassOf NCIT_C129820 @default.
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