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- NCIT_C128293 IAO_0000115 "A tablet-based nutritional supplement composed of a mixture of sprout and seed extracts of the cruciferous vegetable broccoli, with potential chemopreventive and antioxidant activities. Broccoli sprout/broccoli seed extract contains a high amount of both the glycosinolate glucoraphanin and the enzyme myrosinase, which catalyzes the production of glucoraphanin to sulforaphane. Upon administration of the broccoli sprout/broccoli seed extract, sulforaphane activates the transcription factor NF-E2-related factor 2 (Nrf2), a member of the basic leucine zipper family, which binds to and activates antioxidant-response elements (AREs). Subsequently, activated AREs promote the transcription of antioxidant and detoxifying enzymes, particularly glutathione-S-transferase and NAD(P)H dehydrogenase [quinone] 1 (NAD(P)H:quinone oxidoreductase; NQO1), resulting in the detoxification of highly reactive carcinogens. This accelerates the elimination of carcinogens, may protect against cellular damage, and prevents cancer formation. AREs are cis-acting regulatory enhancer elements found in the 5' flanking region of many phase II detoxification enzymes." @default.
- NCIT_C128293 NCIT_A32 NCIT_C1909 @default.
- NCIT_C128293 NCIT_NHC0 "C128293" @default.
- NCIT_C128293 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128293 NCIT_P107 "Broccoli Sprout/Broccoli Seed Extract Supplement" @default.
- NCIT_C128293 NCIT_P108 "Broccoli Sprout/Broccoli Seed Extract Supplement" @default.
- NCIT_C128293 NCIT_P208 "CL507940" @default.
- NCIT_C128293 NCIT_P322 "CTRP" @default.
- NCIT_C128293 NCIT_P322 "GDC" @default.
- NCIT_C128293 NCIT_P329 "782181" @default.
- NCIT_C128293 NCIT_P330 "782181" @default.
- NCIT_C128293 NCIT_P375 "Broccoli Sprout/Broccoli Seed Extract Supplement" @default.
- NCIT_C128293 NCIT_P399 "782181" @default.
- NCIT_C128293 normalizedInformationContent "100" @default.
- NCIT_C128293 referenceCount "1" @default.
- NCIT_C128293 hasExactSynonym "Avmacol" @default.
- NCIT_C128293 hasExactSynonym "Broccoli Sprout/Broccoli Seed Extract Supplement" @default.
- NCIT_C128293 inSubset NCIT_C116977 @default.
- NCIT_C128293 inSubset NCIT_C116978 @default.
- NCIT_C128293 inSubset NCIT_C128784 @default.
- NCIT_C128293 inSubset NCIT_C157711 @default.
- NCIT_C128293 inSubset NCIT_C157712 @default.
- NCIT_C128293 inSubset NCIT_C176424 @default.
- NCIT_C128293 inSubset NCIT_C177537 @default.
- NCIT_C128293 type Class @default.
- NCIT_C128293 isDefinedBy ncit.owl @default.
- NCIT_C128293 label "Broccoli Sprout/Broccoli Seed Extract Supplement" @default.
- NCIT_C128293 subClassOf NCIT_C128293 @default.
- NCIT_C128293 subClassOf NCIT_C1908 @default.
- NCIT_C128293 subClassOf NCIT_C1909 @default.
- NCIT_C128293 subClassOf NCIT_C26170 @default.
- NCIT_C128293 subClassOf NCIT_C275 @default.