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- NCIT_C128485 IAO_0000115 "A preparation of allogeneic, genetically engineered T-lymphocytes transduced with a retroviral vector MSGV1 that encodes a T-cell receptor (TCR) targeting a specific epitope of the human papillomavirus (HPV) type 16 oncoprotein E7 (HPV-16 E7 TCR), with potential antineoplastic activity. The TCR especially recognizes and binds with high affinity to the HPV 16 E7 11-19 epitope. Upon administration, HPV-16 E7 expressing T-cells target and bind to tumor cells expressing the HPV-16 E7 antigen leading to selective cytotoxicity in HLA-A2-positive, HPV-16 E7-expressing tumor cells. HPV16 E7, a tumor-associated antigen (TAA), overexpressed in a variety of tumor cell types while not expressed in normal, healthy cells, plays a key role in tumor cell proliferation. E7 11-19 is a naturally processed epitope of HPV-16 E7 that binds specifically to human leukocyte antigen (HLA)-A*02:01 and that has been isolated from the surface of HPV-16 positive, HLA-A*02:01-positive tumor cells." @default.
- NCIT_C128485 NCIT_A7 NCIT_C1179 @default.
- NCIT_C128485 NCIT_NHC0 "C128485" @default.
- NCIT_C128485 NCIT_P106 "Cell" @default.
- NCIT_C128485 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128485 NCIT_P107 "HPV-16 E7 TCR Expressing T-cells" @default.
- NCIT_C128485 NCIT_P108 "HPV-16 E7 TCR Expressing T-cells" @default.
- NCIT_C128485 NCIT_P208 "CL509618" @default.
- NCIT_C128485 NCIT_P322 "CTRP" @default.
- NCIT_C128485 NCIT_P329 "784048" @default.
- NCIT_C128485 NCIT_P330 "784048" @default.
- NCIT_C128485 NCIT_P399 "784048" @default.
- NCIT_C128485 normalizedInformationContent "100" @default.
- NCIT_C128485 referenceCount "1" @default.
- NCIT_C128485 hasExactSynonym "HPV-16 E7 TCR Expressing T-cells" @default.
- NCIT_C128485 hasExactSynonym "HPV-16 E7 TCR Expressing T-lymphocytes" @default.
- NCIT_C128485 hasExactSynonym "HPV-16 E7 TCR-expressing T Lymphocytes" @default.
- NCIT_C128485 hasExactSynonym "Human Papillomavirus Type 16 E7 TCR Expressing T-cells" @default.
- NCIT_C128485 inSubset NCIT_C116977 @default.
- NCIT_C128485 inSubset NCIT_C116978 @default.
- NCIT_C128485 inSubset NCIT_C128784 @default.
- NCIT_C128485 inSubset NCIT_C176424 @default.
- NCIT_C128485 type Class @default.
- NCIT_C128485 isDefinedBy ncit.owl @default.
- NCIT_C128485 label "HPV-16 E7 TCR Expressing T-cells" @default.
- NCIT_C128485 subClassOf NCIT_C128485 @default.
- NCIT_C128485 subClassOf NCIT_C129820 @default.
- NCIT_C128485 subClassOf NCIT_C129821 @default.
- NCIT_C128485 subClassOf NCIT_C129826 @default.
- NCIT_C128485 subClassOf NCIT_C138180 @default.
- NCIT_C128485 subClassOf NCIT_C142078 @default.
- NCIT_C128485 subClassOf NCIT_C154231 @default.
- NCIT_C128485 subClassOf NCIT_C1908 @default.
- NCIT_C128485 subClassOf NCIT_C1909 @default.
- NCIT_C128485 subClassOf NCIT_C1962 @default.
- NCIT_C128485 subClassOf NCIT_C274 @default.
- NCIT_C128485 subClassOf NCIT_C28676 @default.
- NCIT_C128485 subClassOf NCIT_C307 @default.
- NCIT_C128485 subClassOf NCIT_C308 @default.