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- NCIT_C128556 IAO_0000115 "A preparation of human T-lymphocytes transduced with a recombinant viral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or more binding domains targeting the tumor-associated antigen (TAA) CD22 and fused to one or more co-stimulatory, TCR-signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD22 CAR-expressing T-lymphocytes, express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing B-cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells." @default.
- NCIT_C128556 NCIT_A7 NCIT_C17279 @default.
- NCIT_C128556 NCIT_NHC0 "C128556" @default.
- NCIT_C128556 NCIT_P106 "Cell" @default.
- NCIT_C128556 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128556 NCIT_P107 "Anti-CD22 CAR-expressing T Lymphocytes" @default.
- NCIT_C128556 NCIT_P108 "Anti-CD22 CAR-expressing T Lymphocytes" @default.
- NCIT_C128556 NCIT_P208 "CL507942" @default.
- NCIT_C128556 NCIT_P322 "CTRP" @default.
- NCIT_C128556 NCIT_P329 "782275" @default.
- NCIT_C128556 NCIT_P330 "782275" @default.
- NCIT_C128556 NCIT_P399 "782275" @default.
- NCIT_C128556 normalizedInformationContent "100" @default.
- NCIT_C128556 referenceCount "1" @default.
- NCIT_C128556 hasExactSynonym "Anti-CD22 CAR-expressing T Lymphocytes" @default.
- NCIT_C128556 hasExactSynonym "Anti-CD22 CAR-expressing T-cells" @default.
- NCIT_C128556 hasExactSynonym "CD22 CAR-T" @default.
- NCIT_C128556 inSubset NCIT_C116977 @default.
- NCIT_C128556 inSubset NCIT_C116978 @default.
- NCIT_C128556 inSubset NCIT_C176424 @default.
- NCIT_C128556 type Class @default.
- NCIT_C128556 isDefinedBy ncit.owl @default.
- NCIT_C128556 label "Anti-CD22 CAR-expressing T Lymphocytes" @default.
- NCIT_C128556 subClassOf NCIT_C128556 @default.
- NCIT_C128556 subClassOf NCIT_C129820 @default.
- NCIT_C128556 subClassOf NCIT_C129821 @default.
- NCIT_C128556 subClassOf NCIT_C129826 @default.
- NCIT_C128556 subClassOf NCIT_C137999 @default.
- NCIT_C128556 subClassOf NCIT_C142078 @default.
- NCIT_C128556 subClassOf NCIT_C154231 @default.
- NCIT_C128556 subClassOf NCIT_C1908 @default.
- NCIT_C128556 subClassOf NCIT_C1909 @default.
- NCIT_C128556 subClassOf NCIT_C1962 @default.
- NCIT_C128556 subClassOf NCIT_C201173 @default.
- NCIT_C128556 subClassOf NCIT_C274 @default.
- NCIT_C128556 subClassOf NCIT_C307 @default.
- NCIT_C128556 subClassOf NCIT_C308 @default.