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- NCIT_C128558 IAO_0000115 "A toll-like receptor 4 (TLR4) agonist, with potential immunoadjuvant activity. Upon administration, GSK1795091 binds to and activates TLR4, thereby stimulating dendritic cells (DCs), monocytes and macrophages. This activation results in the production of pro-inflammatory cytokines, including interferon gamma (IFN-g), tumor necrosis factor-alpha (TNF-a) and the interleukins (IL), IL-1 beta, -6 and -12. This may induce a T helper cell-1 (Th1) immune response and, upon co-administration of a vaccine containing tumor-associated antigens (TAAs), activates a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing those TAAs. TLR4, a member of the TLR family, plays a key role in the activation of innate immunity." @default.
- NCIT_C128558 NCIT_NHC0 "C128558" @default.
- NCIT_C128558 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128558 NCIT_P108 "TLR4 Agonist GSK1795091" @default.
- NCIT_C128558 NCIT_P208 "CL507944" @default.
- NCIT_C128558 NCIT_P210 "1233589-81-5" @default.
- NCIT_C128558 NCIT_P319 "5D8VHL5WH5" @default.
- NCIT_C128558 NCIT_P322 "FDA" @default.
- NCIT_C128558 NCIT_P329 "782339" @default.
- NCIT_C128558 NCIT_P330 "782339" @default.
- NCIT_C128558 NCIT_P399 "782339" @default.
- NCIT_C128558 normalizedInformationContent "100" @default.
- NCIT_C128558 referenceCount "1" @default.
- NCIT_C128558 hasExactSynonym "GSK-1795091" @default.
- NCIT_C128558 hasExactSynonym "GSK1795091" @default.
- NCIT_C128558 hasExactSynonym "TLR 4 Agonist GSK1795091" @default.
- NCIT_C128558 hasExactSynonym "TLR4 Agonist GSK1795091" @default.
- NCIT_C128558 hasExactSynonym "Toll-like Receptor 4 Agonist GSK1795091" @default.
- NCIT_C128558 inSubset NCIT_C176424 @default.
- NCIT_C128558 inSubset NCIT_C63923 @default.
- NCIT_C128558 type Class @default.
- NCIT_C128558 isDefinedBy ncit.owl @default.
- NCIT_C128558 label "TLR4 Agonist GSK1795091" @default.
- NCIT_C128558 subClassOf NCIT_C128558 @default.
- NCIT_C128558 subClassOf NCIT_C177174 @default.
- NCIT_C128558 subClassOf NCIT_C1908 @default.
- NCIT_C128558 subClassOf NCIT_C1909 @default.
- NCIT_C128558 subClassOf NCIT_C210 @default.
- NCIT_C128558 subClassOf NCIT_C2139 @default.
- NCIT_C128558 subClassOf NCIT_C2140 @default.
- NCIT_C128558 subClassOf NCIT_C2554 @default.
- NCIT_C128558 subClassOf NCIT_C308 @default.