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- NCIT_C128615 IAO_0000115 "An orally available, small molecule and selective ATP-competitive pan-inhibitor of proviral integration sites for Moloney murine leukemia virus (PIM) kinases, with potential antineoplastic activity. Upon oral administration, pan-PIM kinase inhibitor NVP-LGB-321 binds to and prevents the activation of the three PIM family kinases, PIM1, PIM2 and PIM3. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIMs. PIMs, constitutively active proto-oncogenic serine/threonine kinases upregulated in various types of cancers, play key roles in tumor cell proliferation and survival." @default.
- NCIT_C128615 NCIT_A32 NCIT_C1909 @default.
- NCIT_C128615 NCIT_A7 NCIT_C104800 @default.
- NCIT_C128615 NCIT_A7 NCIT_C178145 @default.
- NCIT_C128615 NCIT_A7 NCIT_C18600 @default.
- NCIT_C128615 NCIT_NHC0 "C128615" @default.
- NCIT_C128615 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128615 NCIT_P107 "pan-PIM Kinase Inhibitor NVP-LGB-321" @default.
- NCIT_C128615 NCIT_P108 "pan-PIM Kinase Inhibitor NVP-LGB-321" @default.
- NCIT_C128615 NCIT_P208 "CL509289" @default.
- NCIT_C128615 NCIT_P322 "CTRP" @default.
- NCIT_C128615 NCIT_P322 "GDC" @default.
- NCIT_C128615 NCIT_P375 "pan-PIM Kinase Inhibitor NVP-LGB-321" @default.
- NCIT_C128615 normalizedInformationContent "100" @default.
- NCIT_C128615 referenceCount "1" @default.
- NCIT_C128615 hasExactSynonym "LGB321" @default.
- NCIT_C128615 hasExactSynonym "NVP-LGB-321" @default.
- NCIT_C128615 hasExactSynonym "PIM Inhibitor NVP-LGB-321" @default.
- NCIT_C128615 hasExactSynonym "PIM Kinase Inhibitor NVP-LGB-321" @default.
- NCIT_C128615 hasExactSynonym "pan-PIM Kinase Inhibitor NVP-LGB-321" @default.
- NCIT_C128615 inSubset NCIT_C116977 @default.
- NCIT_C128615 inSubset NCIT_C116978 @default.
- NCIT_C128615 inSubset NCIT_C128784 @default.
- NCIT_C128615 inSubset NCIT_C157711 @default.
- NCIT_C128615 inSubset NCIT_C157712 @default.
- NCIT_C128615 inSubset NCIT_C177537 @default.
- NCIT_C128615 type Class @default.
- NCIT_C128615 isDefinedBy ncit.owl @default.
- NCIT_C128615 label "pan-PIM Kinase Inhibitor NVP-LGB-321" @default.
- NCIT_C128615 subClassOf NCIT_C128615 @default.
- NCIT_C128615 subClassOf NCIT_C1404 @default.
- NCIT_C128615 subClassOf NCIT_C1908 @default.
- NCIT_C128615 subClassOf NCIT_C1909 @default.
- NCIT_C128615 subClassOf NCIT_C471 @default.
- NCIT_C128615 subClassOf NCIT_C61074 @default.