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- NCIT_C128862 IAO_0000115 "An orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis." @default.
- NCIT_C128862 NCIT_A32 NCIT_C1909 @default.
- NCIT_C128862 NCIT_A7 NCIT_C25859 @default.
- NCIT_C128862 NCIT_NHC0 "C128862" @default.
- NCIT_C128862 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128862 NCIT_P107 "FGFR4 Inhibitor H3B-6527" @default.
- NCIT_C128862 NCIT_P108 "FGFR4 Inhibitor H3B-6527" @default.
- NCIT_C128862 NCIT_P208 "CL512384" @default.
- NCIT_C128862 NCIT_P210 "1702259-66-2" @default.
- NCIT_C128862 NCIT_P319 "4HTE364XIK" @default.
- NCIT_C128862 NCIT_P322 "CTRP" @default.
- NCIT_C128862 NCIT_P322 "FDA" @default.
- NCIT_C128862 NCIT_P322 "GDC" @default.
- NCIT_C128862 NCIT_P329 "783108" @default.
- NCIT_C128862 NCIT_P330 "783108" @default.
- NCIT_C128862 NCIT_P375 "FGFR4 Inhibitor H3B-6527" @default.
- NCIT_C128862 NCIT_P399 "783108" @default.
- NCIT_C128862 normalizedInformationContent "100" @default.
- NCIT_C128862 referenceCount "1" @default.
- NCIT_C128862 hasExactSynonym "FGFR4 Inhibitor H3B-6527" @default.
- NCIT_C128862 hasExactSynonym "Fibroblast Growth Factor Receptor 4 Inhibitor H3B-6527" @default.
- NCIT_C128862 hasExactSynonym "H3B 6527" @default.
- NCIT_C128862 hasExactSynonym "H3B-6527" @default.
- NCIT_C128862 hasExactSynonym "H3B6527" @default.
- NCIT_C128862 inSubset NCIT_C116977 @default.
- NCIT_C128862 inSubset NCIT_C116978 @default.
- NCIT_C128862 inSubset NCIT_C128784 @default.
- NCIT_C128862 inSubset NCIT_C157711 @default.
- NCIT_C128862 inSubset NCIT_C157712 @default.
- NCIT_C128862 inSubset NCIT_C176424 @default.
- NCIT_C128862 inSubset NCIT_C177537 @default.
- NCIT_C128862 inSubset NCIT_C63923 @default.
- NCIT_C128862 type Class @default.
- NCIT_C128862 isDefinedBy ncit.owl @default.
- NCIT_C128862 label "FGFR4 Inhibitor H3B-6527" @default.
- NCIT_C128862 subClassOf NCIT_C128862 @default.
- NCIT_C128862 subClassOf NCIT_C129824 @default.
- NCIT_C128862 subClassOf NCIT_C129825 @default.
- NCIT_C128862 subClassOf NCIT_C1404 @default.
- NCIT_C128862 subClassOf NCIT_C155727 @default.
- NCIT_C128862 subClassOf NCIT_C163758 @default.
- NCIT_C128862 subClassOf NCIT_C164035 @default.
- NCIT_C128862 subClassOf NCIT_C1908 @default.
- NCIT_C128862 subClassOf NCIT_C1909 @default.
- NCIT_C128862 subClassOf NCIT_C1967 @default.
- NCIT_C128862 subClassOf NCIT_C2189 @default.
- NCIT_C128862 subClassOf NCIT_C274 @default.
- NCIT_C128862 subClassOf NCIT_C471 @default.