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- NCIT_C128892 IAO_0000115 "A preparation of autologous cytotoxic T-lymphocytes (CTL), specifically reactive to melanoma-associated antigen 3 (MAGE-3), MAGE-4, survivin, human epidermal growth factor receptor 2 (HER2; ERBB2) and cyclooxygenase-2 (COX-2), with potential immunomodulating activity. Peripheral blood mononuclear cells (PBMCs) are collected from the patient. Subsequently, autologous dendritic cells (DCs) are separated, treated with a certain combination of cytokines to produce polarized type-1 DCs (DC1), and then are loaded with MAGE-3/MAGE-4/survivin/HER2/COX-2 CTL epitope peptides. In turn, autologous CTLs are collected, exposed ex vivo to the antigen-loaded DC1s and subsequently expanded in vitro. Upon re-infusion of the DC1-induced MAGE-3/MAGE-4/survivin/HER2/COX-2-specific autologous CTLs, the CTLs target and lyse tumor cells expressing the tumor-associated antigens (TAAs). Exposure to DC1s generates more potent CTLs and thus induces a more potent CTL response against TAA-expressing tumor cells. The targeted TAAs play key roles in cellular proliferation and are overexpressed by a variety of cancer cell types." @default.
- NCIT_C128892 NCIT_NHC0 "C128892" @default.
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- NCIT_C128892 NCIT_P108 "Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes" @default.
- NCIT_C128892 NCIT_P208 "CL512380" @default.
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- NCIT_C128892 hasExactSynonym "Autologous DC1-CTL" @default.
- NCIT_C128892 hasExactSynonym "DC1-induced Antigen-specific Autologous CTLs" @default.
- NCIT_C128892 hasExactSynonym "Type-1 Polarized DC-induced Antigen-specific Autologous CTLs" @default.
- NCIT_C128892 hasExactSynonym "Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes" @default.
- NCIT_C128892 inSubset NCIT_C128784 @default.
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- NCIT_C128892 type Class @default.
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- NCIT_C128892 label "Type-1 Polarized Dendritic Cell-induced Antigen-specific Autologous Cytotoxic T Lymphocytes" @default.
- NCIT_C128892 subClassOf NCIT_C128892 @default.
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- NCIT_C128892 subClassOf NCIT_C307 @default.
- NCIT_C128892 subClassOf NCIT_C308 @default.