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- NCIT_C128897 IAO_0000115 "A nanocell formulation targeting the epidermal growth factor receptor (EGFR) using bispecific antibodies (bsAb) against EGFR and containing the antineoplastic anthracycline antibiotic doxorubicin, with potential antineoplastic activity. Upon administration of doxorubicin-loaded EGFR-targeting nanocells, the nanocells are stable in the bloodstream and the anti-EGFR bsAb moiety targets and binds to EGFR-expressing tumor cells. Upon binding, the nanocell allows for specific delivery of doxorubicin to tumor cells overexpressing EGFR. Upon endocytosis by the tumor cells, the nanocell is broken down and releases doxorubicin, which intercalates into DNA and interferes with topoisomerase II activity, thereby inhibiting DNA replication and RNA synthesis. Compared to doxorubicin alone or liposomal doxorubicin, targeted delivery of doxorubicin improves efficacy while lowering the toxicity profile. EGFR, a tyrosine kinase receptor, is overexpressed in many cancer cell types. The nanocell is a bacterially derived nanosphere; the bacterial components are unlikely to induce an immune response in the immunosuppressed tumor microenvironment." @default.
- NCIT_C128897 NCIT_A32 NCIT_C1909 @default.
- NCIT_C128897 NCIT_A7 NCIT_C17068 @default.
- NCIT_C128897 NCIT_NHC0 "C128897" @default.
- NCIT_C128897 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C128897 NCIT_P107 "Doxorubicin-loaded EGFR-targeting Nanocells" @default.
- NCIT_C128897 NCIT_P108 "Doxorubicin-loaded EGFR-targeting Nanocells" @default.
- NCIT_C128897 NCIT_P208 "CL512145" @default.
- NCIT_C128897 NCIT_P322 "CTRP" @default.
- NCIT_C128897 NCIT_P322 "GDC" @default.
- NCIT_C128897 NCIT_P329 "782631" @default.
- NCIT_C128897 NCIT_P330 "782631" @default.
- NCIT_C128897 NCIT_P375 "Doxorubicin-loaded EGFR-targeting Nanocells" @default.
- NCIT_C128897 NCIT_P399 "782631" @default.
- NCIT_C128897 normalizedInformationContent "100" @default.
- NCIT_C128897 referenceCount "1" @default.
- NCIT_C128897 hasExactSynonym "Doxorubicin-loaded EGFR-targeting Nanocell" @default.
- NCIT_C128897 hasExactSynonym "Doxorubicin-loaded EGFR-targeting Nanocells" @default.
- NCIT_C128897 hasExactSynonym "EGFR (Vectibix Sequence)-Targeted EnGeneIC Dream Vectors Containing Doxorubicin" @default.
- NCIT_C128897 hasExactSynonym "EGFR(V)-EDV-Dox" @default.
- NCIT_C128897 hasExactSynonym "EGFR-targeted EnGeneIC Dream Vectors Containing Doxorubicin" @default.
- NCIT_C128897 inSubset NCIT_C116977 @default.
- NCIT_C128897 inSubset NCIT_C116978 @default.
- NCIT_C128897 inSubset NCIT_C128784 @default.
- NCIT_C128897 inSubset NCIT_C157711 @default.
- NCIT_C128897 inSubset NCIT_C157712 @default.
- NCIT_C128897 inSubset NCIT_C176424 @default.
- NCIT_C128897 inSubset NCIT_C177537 @default.
- NCIT_C128897 type Class @default.
- NCIT_C128897 isDefinedBy ncit.owl @default.
- NCIT_C128897 label "Doxorubicin-loaded EGFR-targeting Nanocells" @default.
- NCIT_C128897 subClassOf NCIT_C128897 @default.
- NCIT_C128897 subClassOf NCIT_C129824 @default.
- NCIT_C128897 subClassOf NCIT_C129825 @default.
- NCIT_C128897 subClassOf NCIT_C1594 @default.
- NCIT_C128897 subClassOf NCIT_C163758 @default.
- NCIT_C128897 subClassOf NCIT_C163952 @default.
- NCIT_C128897 subClassOf NCIT_C1748 @default.
- NCIT_C128897 subClassOf NCIT_C186664 @default.
- NCIT_C128897 subClassOf NCIT_C1908 @default.
- NCIT_C128897 subClassOf NCIT_C1909 @default.
- NCIT_C128897 subClassOf NCIT_C1968 @default.
- NCIT_C128897 subClassOf NCIT_C2115 @default.
- NCIT_C128897 subClassOf NCIT_C2161 @default.
- NCIT_C128897 subClassOf NCIT_C2189 @default.
- NCIT_C128897 subClassOf NCIT_C259 @default.
- NCIT_C128897 subClassOf NCIT_C274 @default.
- NCIT_C128897 subClassOf NCIT_C2842 @default.
- NCIT_C128897 subClassOf NCIT_C471 @default.
- NCIT_C128897 subClassOf NCIT_C67502 @default.