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- NCIT_C129015 IAO_0000115 "An orally bioavailable inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with activity against HCV genotype 1. Upon administration, simeprevir reversibly binds to the active center and binding site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, which inhibits viral replication in HCV genotype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family; HCV infection is associated with the development of hepatocellular carcinoma (HCC)." @default.
- NCIT_C129015 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129015 NCIT_NHC0 "C129015" @default.
- NCIT_C129015 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129015 NCIT_P108 "Simeprevir" @default.
- NCIT_C129015 NCIT_P207 "C2605855" @default.
- NCIT_C129015 NCIT_P210 "923604-59-5" @default.
- NCIT_C129015 NCIT_P319 "9WS5RD66HZ" @default.
- NCIT_C129015 NCIT_P322 "FDA" @default.
- NCIT_C129015 NCIT_P322 "GDC" @default.
- NCIT_C129015 NCIT_P329 "783151" @default.
- NCIT_C129015 NCIT_P330 "783151" @default.
- NCIT_C129015 NCIT_P375 "Simeprevir" @default.
- NCIT_C129015 NCIT_P399 "783151" @default.
- NCIT_C129015 normalizedInformationContent "100" @default.
- NCIT_C129015 referenceCount "1" @default.
- NCIT_C129015 hasExactSynonym "HSDB 8227" @default.
- NCIT_C129015 hasExactSynonym "N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide" @default.
- NCIT_C129015 hasExactSynonym "Olysio" @default.
- NCIT_C129015 hasExactSynonym "SIMEPREVIR" @default.
- NCIT_C129015 hasExactSynonym "Simeprevir" @default.
- NCIT_C129015 hasExactSynonym "TMC 435" @default.
- NCIT_C129015 hasExactSynonym "TMC-435" @default.
- NCIT_C129015 hasExactSynonym "TMC435" @default.
- NCIT_C129015 inSubset NCIT_C128784 @default.
- NCIT_C129015 inSubset NCIT_C157711 @default.
- NCIT_C129015 inSubset NCIT_C157712 @default.
- NCIT_C129015 inSubset NCIT_C176424 @default.
- NCIT_C129015 inSubset NCIT_C177537 @default.
- NCIT_C129015 inSubset NCIT_C63923 @default.
- NCIT_C129015 type Class @default.
- NCIT_C129015 isDefinedBy ncit.owl @default.
- NCIT_C129015 label "Simeprevir" @default.
- NCIT_C129015 subClassOf NCIT_C129015 @default.
- NCIT_C129015 subClassOf NCIT_C1908 @default.
- NCIT_C129015 subClassOf NCIT_C1909 @default.
- NCIT_C129015 subClassOf NCIT_C471 @default.
- NCIT_C129015 subClassOf NCIT_C783 @default.