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- NCIT_C129401 IAO_0000115 "A monoclonal antibody-drug conjugate (ADC) comprised of human immunoglobulin G1 (IgG1) clone CR014, which targets the extracellular domain of T-cell immunoglobulin mucin-1 (TIM-1; HAVCR1), that is linked, via a valine-citrulline (VC) peptide linker, to the potent cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of ADC anti-TIM-1-vcMMAE CDX-014, the monoclonal antibody moiety targets and binds to TIM-1. Upon internalization and proteolytic cleavage, MMAE is released into the cytosol of TIM-1-expressing tumor cells, binds to tubulin, and inhibits microtubule polymerization, which induces both G2/M phase arrest and tumor cell apoptosis. TIM-1 is upregulated in a variety of cancer cell types while only minimally expressed in healthy tissue. The linkage system in CDX-014 is highly stable in plasma, resulting in increased specificity and cytotoxic efficacy towards TIM-1-positive cells." @default.
- NCIT_C129401 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129401 NCIT_A7 NCIT_C116608 @default.
- NCIT_C129401 NCIT_NHC0 "C129401" @default.
- NCIT_C129401 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129401 NCIT_P107 "Antibody-drug Conjugate Anti-TIM-1-vcMMAE CDX-014" @default.
- NCIT_C129401 NCIT_P108 "Antibody-drug Conjugate Anti-TIM-1-vcMMAE CDX-014" @default.
- NCIT_C129401 NCIT_P208 "CL512670" @default.
- NCIT_C129401 NCIT_P319 "GJV1PP34M2" @default.
- NCIT_C129401 NCIT_P322 "CTRP" @default.
- NCIT_C129401 NCIT_P322 "FDA" @default.
- NCIT_C129401 NCIT_P322 "GDC" @default.
- NCIT_C129401 NCIT_P329 "783989" @default.
- NCIT_C129401 NCIT_P330 "783989" @default.
- NCIT_C129401 NCIT_P375 "Antibody-drug Conjugate Anti-TIM-1-vcMMAE CDX-014" @default.
- NCIT_C129401 NCIT_P399 "783989" @default.
- NCIT_C129401 normalizedInformationContent "100" @default.
- NCIT_C129401 referenceCount "1" @default.
- NCIT_C129401 hasExactSynonym "ADC Anti-TIM-1-vcMMAE CDX-014" @default.
- NCIT_C129401 hasExactSynonym "ADC CDX-014" @default.
- NCIT_C129401 hasExactSynonym "Antibody-drug Conjugate Anti-TIM-1-vcMMAE CDX-014" @default.
- NCIT_C129401 hasExactSynonym "Antibody-drug Conjugate CDX-014" @default.
- NCIT_C129401 hasExactSynonym "CDX-014" @default.
- NCIT_C129401 hasExactSynonym "CR014-vc-MMAE" @default.
- NCIT_C129401 hasExactSynonym "CR014-vcMMAE" @default.
- NCIT_C129401 inSubset NCIT_C116977 @default.
- NCIT_C129401 inSubset NCIT_C116978 @default.
- NCIT_C129401 inSubset NCIT_C128784 @default.
- NCIT_C129401 inSubset NCIT_C157711 @default.
- NCIT_C129401 inSubset NCIT_C157712 @default.
- NCIT_C129401 inSubset NCIT_C176424 @default.
- NCIT_C129401 inSubset NCIT_C177537 @default.
- NCIT_C129401 inSubset NCIT_C63923 @default.
- NCIT_C129401 type Class @default.
- NCIT_C129401 isDefinedBy ncit.owl @default.
- NCIT_C129401 label "Antibody-drug Conjugate Anti-TIM-1-vcMMAE CDX-014" @default.
- NCIT_C129401 subClassOf NCIT_C129401 @default.
- NCIT_C129401 subClassOf NCIT_C129821 @default.
- NCIT_C129401 subClassOf NCIT_C129823 @default.
- NCIT_C129401 subClassOf NCIT_C1512 @default.
- NCIT_C129401 subClassOf NCIT_C1908 @default.
- NCIT_C129401 subClassOf NCIT_C1909 @default.
- NCIT_C129401 subClassOf NCIT_C274 @default.
- NCIT_C129401 subClassOf NCIT_C307 @default.
- NCIT_C129401 subClassOf NCIT_C308 @default.