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- NCIT_C129448 IAO_0000115 "A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 protein (PD-1, PCDC-1), with potential immune checkpoint inhibitory and antineoplastic activity. Upon administration, cetrelimab binds to PD-1, and inhibits the interaction with its ligands, programmed cell death 1 ligand 1 (PD-L1, PD-1L1) and PD-1 ligand 2 (PD-L2, PD-1L2). The inhibition of ligand binding prevents PD-1-mediated signaling and results in both T-cell activation and the induction of T-cell-mediated immune responses against tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation." @default.
- NCIT_C129448 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129448 NCIT_A7 NCIT_C94697 @default.
- NCIT_C129448 NCIT_NHC0 "C129448" @default.
- NCIT_C129448 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C129448 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C129448 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129448 NCIT_P107 "Cetrelimab" @default.
- NCIT_C129448 NCIT_P108 "Cetrelimab" @default.
- NCIT_C129448 NCIT_P208 "CL512668" @default.
- NCIT_C129448 NCIT_P210 "2050478-92-5" @default.
- NCIT_C129448 NCIT_P319 "LYK98WP91F" @default.
- NCIT_C129448 NCIT_P322 "CTRP" @default.
- NCIT_C129448 NCIT_P322 "FDA" @default.
- NCIT_C129448 NCIT_P322 "GDC" @default.
- NCIT_C129448 NCIT_P329 "784126" @default.
- NCIT_C129448 NCIT_P330 "784126" @default.
- NCIT_C129448 NCIT_P375 "Cetrelimab" @default.
- NCIT_C129448 NCIT_P399 "784126" @default.
- NCIT_C129448 NCIT_R124 NCIT_C17710 @default.
- NCIT_C129448 NCIT_R124 NCIT_C17828 @default.
- NCIT_C129448 NCIT_R124 NCIT_C18219 @default.
- NCIT_C129448 NCIT_R124 NCIT_C19986 @default.
- NCIT_C129448 NCIT_R124 NCIT_C40474 @default.
- NCIT_C129448 normalizedInformationContent "100" @default.
- NCIT_C129448 referenceCount "1" @default.
- NCIT_C129448 hasExactSynonym "CETRELIMAB" @default.
- NCIT_C129448 hasExactSynonym "Cetrelimab" @default.
- NCIT_C129448 hasExactSynonym "JNJ 63723283" @default.
- NCIT_C129448 hasExactSynonym "JNJ-63723283" @default.
- NCIT_C129448 hasExactSynonym "JNJ63723283" @default.
- NCIT_C129448 hasExactSynonym "WHO 10757" @default.
- NCIT_C129448 inSubset NCIT_C116977 @default.
- NCIT_C129448 inSubset NCIT_C116978 @default.
- NCIT_C129448 inSubset NCIT_C128784 @default.
- NCIT_C129448 inSubset NCIT_C157711 @default.
- NCIT_C129448 inSubset NCIT_C157712 @default.
- NCIT_C129448 inSubset NCIT_C176424 @default.
- NCIT_C129448 inSubset NCIT_C177537 @default.
- NCIT_C129448 inSubset NCIT_C63923 @default.
- NCIT_C129448 type Class @default.
- NCIT_C129448 isDefinedBy ncit.owl @default.
- NCIT_C129448 label "Cetrelimab" @default.
- NCIT_C129448 subClassOf NCIT_C124946 @default.
- NCIT_C129448 subClassOf NCIT_C128037 @default.
- NCIT_C129448 subClassOf NCIT_C129448 @default.
- NCIT_C129448 subClassOf NCIT_C141144 @default.
- NCIT_C129448 subClassOf NCIT_C143250 @default.
- NCIT_C129448 subClassOf NCIT_C163758 @default.
- NCIT_C129448 subClassOf NCIT_C1908 @default.
- NCIT_C129448 subClassOf NCIT_C1909 @default.
- NCIT_C129448 subClassOf NCIT_C20401 @default.
- NCIT_C129448 subClassOf NCIT_C274 @default.
- NCIT_C129448 subClassOf NCIT_C307 @default.
- NCIT_C129448 subClassOf NCIT_C308 @default.