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- NCIT_C129457 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of an anti-CD123 humanized monoclonal antibody conjugated, via a stable maleimidocaproyl-valine-alanine dipeptide protease-cleavable linker, to the cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. Upon administration of anti-CD123 ADC SGN-CD123A, the antibody moiety targets the cell surface antigen CD123. Upon antibody/antigen binding, internalization, and lysosome uptake, the cytotoxic PBD moiety is released. In turn, the imine groups of the PBD moiety bind to the N2 positions of guanines on opposite strands of DNA. This induces DNA strand breaks, inhibits DNA replication, leads to G2/M cell cycle arrest, induces cell death, and inhibits the proliferation of CD123-overexpressing tumor cells. CD123, the alpha subunit of the IL-3 receptor, regulates the proliferation, survival and differentiation of hematopoietic cells. CD123 is overexpressed on a variety of cancers, including myeloid leukemia, and increased expression of CD123 on leukemic stem cells is associated with poor prognosis. Cysteine engineering of the monoclonal antibody (EC-mAb) allows for a site-specific, stable conjugation and uniform loading of the PBD agent to the antibody." @default.
- NCIT_C129457 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129457 NCIT_A7 NCIT_C39275 @default.
- NCIT_C129457 NCIT_NHC0 "C129457" @default.
- NCIT_C129457 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C129457 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C129457 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129457 NCIT_P107 "Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A" @default.
- NCIT_C129457 NCIT_P108 "Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A" @default.
- NCIT_C129457 NCIT_P208 "CL512667" @default.
- NCIT_C129457 NCIT_P319 "89ATB9I3D2" @default.
- NCIT_C129457 NCIT_P322 "CTRP" @default.
- NCIT_C129457 NCIT_P322 "FDA" @default.
- NCIT_C129457 NCIT_P322 "GDC" @default.
- NCIT_C129457 NCIT_P329 "784132" @default.
- NCIT_C129457 NCIT_P330 "784132" @default.
- NCIT_C129457 NCIT_P375 "Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A" @default.
- NCIT_C129457 NCIT_P399 "784132" @default.
- NCIT_C129457 normalizedInformationContent "100" @default.
- NCIT_C129457 referenceCount "1" @default.
- NCIT_C129457 hasExactSynonym "ADC SGN-CD123A" @default.
- NCIT_C129457 hasExactSynonym "Anti-CD123 ADC SGN-CD123A" @default.
- NCIT_C129457 hasExactSynonym "Anti-CD123-PBD ADC SGN-CD123A" @default.
- NCIT_C129457 hasExactSynonym "Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A" @default.
- NCIT_C129457 hasExactSynonym "Antibody-drug Conjugate SGN-CD123A" @default.
- NCIT_C129457 hasExactSynonym "SGN CD123A" @default.
- NCIT_C129457 hasExactSynonym "SGN-CD123A" @default.
- NCIT_C129457 inSubset NCIT_C116977 @default.
- NCIT_C129457 inSubset NCIT_C116978 @default.
- NCIT_C129457 inSubset NCIT_C128784 @default.
- NCIT_C129457 inSubset NCIT_C157711 @default.
- NCIT_C129457 inSubset NCIT_C157712 @default.
- NCIT_C129457 inSubset NCIT_C176424 @default.
- NCIT_C129457 inSubset NCIT_C177537 @default.
- NCIT_C129457 inSubset NCIT_C63923 @default.
- NCIT_C129457 type Class @default.
- NCIT_C129457 isDefinedBy ncit.owl @default.
- NCIT_C129457 label "Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A" @default.
- NCIT_C129457 subClassOf NCIT_C129457 @default.
- NCIT_C129457 subClassOf NCIT_C129821 @default.
- NCIT_C129457 subClassOf NCIT_C129823 @default.
- NCIT_C129457 subClassOf NCIT_C1512 @default.
- NCIT_C129457 subClassOf NCIT_C1908 @default.
- NCIT_C129457 subClassOf NCIT_C1909 @default.
- NCIT_C129457 subClassOf NCIT_C274 @default.
- NCIT_C129457 subClassOf NCIT_C307 @default.
- NCIT_C129457 subClassOf NCIT_C308 @default.