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- NCIT_C129546 IAO_0000115 "An orally bioavailable inhibitor of the splicing factor 3B subunit 1 (SF3B1), with potential antineoplastic activity. Upon administration, H3B-8800 binds to and blocks the activity of SF3B1, a core spliceosome protein that is mutated in various cancer cells. This modulates RNA splicing by preventing aberrant mRNA splicing by the spliceosome, blocks RNA mis-splicing, enhances proper RNA splicing and prevents the expression of certain tumor-associated genes. This leads to an induction of apoptosis and prevents tumor cell proliferation. In many cancer cells, core spliceosome proteins, including SF3B1, U2 small nuclear ribonucleoprotein auxiliary factor 1 (U2AF1), serine/arginine-rich splicing factor 2 (SRSF2) and U2 small nuclear ribonucleoprotein auxiliary factor subunit-related protein 2 (ZRSR2), are mutated and aberrantly activated leading to a dysregulation of mRNA splicing." @default.
- NCIT_C129546 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129546 NCIT_A7 NCIT_C98286 @default.
- NCIT_C129546 NCIT_NHC0 "C129546" @default.
- NCIT_C129546 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129546 NCIT_P107 "Splicing Inhibitor H3B-8800" @default.
- NCIT_C129546 NCIT_P108 "Splicing Inhibitor H3B-8800" @default.
- NCIT_C129546 NCIT_P208 "CL512654" @default.
- NCIT_C129546 NCIT_P210 "1825302-42-8" @default.
- NCIT_C129546 NCIT_P319 "90YLS47BRX" @default.
- NCIT_C129546 NCIT_P322 "CTRP" @default.
- NCIT_C129546 NCIT_P322 "FDA" @default.
- NCIT_C129546 NCIT_P322 "GDC" @default.
- NCIT_C129546 NCIT_P329 "784315" @default.
- NCIT_C129546 NCIT_P330 "784315" @default.
- NCIT_C129546 NCIT_P375 "Splicing Inhibitor H3B-8800" @default.
- NCIT_C129546 NCIT_P399 "784315" @default.
- NCIT_C129546 normalizedInformationContent "100" @default.
- NCIT_C129546 referenceCount "1" @default.
- NCIT_C129546 hasExactSynonym "H3B 8800" @default.
- NCIT_C129546 hasExactSynonym "H3B-8800" @default.
- NCIT_C129546 hasExactSynonym "Splicing Factor Inhibitor H3B-8800" @default.
- NCIT_C129546 hasExactSynonym "Splicing Inhibitor H3B-8800" @default.
- NCIT_C129546 hasExactSynonym "Splicing Modulator H3B-8800" @default.
- NCIT_C129546 inSubset NCIT_C116977 @default.
- NCIT_C129546 inSubset NCIT_C116978 @default.
- NCIT_C129546 inSubset NCIT_C128784 @default.
- NCIT_C129546 inSubset NCIT_C157711 @default.
- NCIT_C129546 inSubset NCIT_C157712 @default.
- NCIT_C129546 inSubset NCIT_C176424 @default.
- NCIT_C129546 inSubset NCIT_C177537 @default.
- NCIT_C129546 inSubset NCIT_C63923 @default.
- NCIT_C129546 type Class @default.
- NCIT_C129546 isDefinedBy ncit.owl @default.
- NCIT_C129546 label "Splicing Inhibitor H3B-8800" @default.
- NCIT_C129546 subClassOf NCIT_C129546 @default.
- NCIT_C129546 subClassOf NCIT_C129824 @default.
- NCIT_C129546 subClassOf NCIT_C1908 @default.
- NCIT_C129546 subClassOf NCIT_C1909 @default.
- NCIT_C129546 subClassOf NCIT_C2189 @default.
- NCIT_C129546 subClassOf NCIT_C274 @default.