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- NCIT_C129555 IAO_0000115 "A ketone and an amino acid derivative that is synthesized by either tryptophan 2,3-dioxygenase (TDO)- or indoleamine 2,3-dioxygenase (IDO)-mediated oxidation of tryptophan with diverse biological functions, including vasodilatory, immunoregulatory and neuromodulatory activities. Kynurenine is a precursor for niacin. Additionally, kynurenine can be further metabolized into anthranilic acid, kynurenic acid, and 3-hydroxykynurenine; aberrant production of kynurenine is associated with neurological disease-related cognitive deficits and depressive symptoms. Overexpressed in certain cancer cell types, kynurenine could potentially be used as a biomarker to assess cancer risk." @default.
- NCIT_C129555 NCIT_NHC0 "C129555" @default.
- NCIT_C129555 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C129555 NCIT_P107 "Kynurenine" @default.
- NCIT_C129555 NCIT_P108 "Kynurenine" @default.
- NCIT_C129555 NCIT_P207 "C0022818" @default.
- NCIT_C129555 NCIT_P210 "2922-83-0" @default.
- NCIT_C129555 NCIT_P319 "02JW4J5R44" @default.
- NCIT_C129555 NCIT_P322 "CTRP" @default.
- NCIT_C129555 NCIT_P322 "FDA" @default.
- NCIT_C129555 NCIT_P368 "CHEBI:16946" @default.
- NCIT_C129555 normalizedInformationContent "100" @default.
- NCIT_C129555 referenceCount "1" @default.
- NCIT_C129555 hasExactSynonym "(2S)-2-Amino-4-(2-Aminophenyl)-4-Oxobutanoic Acid" @default.
- NCIT_C129555 hasExactSynonym "(S)-Kynurenine" @default.
- NCIT_C129555 hasExactSynonym "3-Anthraniloyl-L-Alanine" @default.
- NCIT_C129555 hasExactSynonym "KYN" @default.
- NCIT_C129555 hasExactSynonym "KYNURENINE" @default.
- NCIT_C129555 hasExactSynonym "Kynurenine" @default.
- NCIT_C129555 hasExactSynonym "Kynurenine, L-" @default.
- NCIT_C129555 hasExactSynonym "L-Kynurenine" @default.
- NCIT_C129555 inSubset NCIT_C116977 @default.
- NCIT_C129555 inSubset NCIT_C142799 @default.
- NCIT_C129555 inSubset NCIT_C63923 @default.
- NCIT_C129555 type Class @default.
- NCIT_C129555 isDefinedBy ncit.owl @default.
- NCIT_C129555 label "Kynurenine" @default.
- NCIT_C129555 subClassOf NCIT_C129555 @default.
- NCIT_C129555 subClassOf NCIT_C1908 @default.
- NCIT_C129555 subClassOf NCIT_C1913 @default.
- NCIT_C129555 subClassOf NCIT_C200714 @default.
- NCIT_C129555 subClassOf NCIT_C232 @default.
- NCIT_C129555 subClassOf NCIT_C718 @default.
- NCIT_C129555 subClassOf NCIT_C73539 @default.