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- NCIT_C129580 IAO_0000115 "An orally bioavailable inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization activities. Upon oral administration, chk1 inhibitor SRA737 selectively binds to chk1, thereby preventing chk1 activity and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest, and induction of apoptosis. SRA737 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. Chk1, an adenosine triphosphate (ATP)-dependent serine/threonine kinase overexpressed in a variety of cancer cell types, mediates cell cycle checkpoint control and is essential for DNA repair; it plays a key role in resistance to chemotherapeutic agents by repairing DNA damage." @default.
- NCIT_C129580 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129580 NCIT_NHC0 "C129580" @default.
- NCIT_C129580 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129580 NCIT_P108 "Chk1 Inhibitor SRA737" @default.
- NCIT_C129580 NCIT_P208 "CL512598" @default.
- NCIT_C129580 NCIT_P210 "1489389-18-5" @default.
- NCIT_C129580 NCIT_P319 "QB6LNL4NF6" @default.
- NCIT_C129580 NCIT_P322 "FDA" @default.
- NCIT_C129580 NCIT_P322 "GDC" @default.
- NCIT_C129580 NCIT_P329 "783792" @default.
- NCIT_C129580 NCIT_P330 "783792" @default.
- NCIT_C129580 NCIT_P375 "Chk1 Inhibitor CCT245737" @default.
- NCIT_C129580 NCIT_P399 "783792" @default.
- NCIT_C129580 normalizedInformationContent "100" @default.
- NCIT_C129580 referenceCount "1" @default.
- NCIT_C129580 hasExactSynonym "(R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile" @default.
- NCIT_C129580 hasExactSynonym "CCT245737" @default.
- NCIT_C129580 hasExactSynonym "Checkpoint Kinase 1 Inhibitor CCT245737" @default.
- NCIT_C129580 hasExactSynonym "Chk1 Inhibitor CCT245737" @default.
- NCIT_C129580 hasExactSynonym "Chk1 Inhibitor SRA737" @default.
- NCIT_C129580 hasExactSynonym "PNT-737" @default.
- NCIT_C129580 hasExactSynonym "SRA 737" @default.
- NCIT_C129580 hasExactSynonym "SRA-737" @default.
- NCIT_C129580 hasExactSynonym "SRA737" @default.
- NCIT_C129580 inSubset NCIT_C128784 @default.
- NCIT_C129580 inSubset NCIT_C157711 @default.
- NCIT_C129580 inSubset NCIT_C157712 @default.
- NCIT_C129580 inSubset NCIT_C176424 @default.
- NCIT_C129580 inSubset NCIT_C177537 @default.
- NCIT_C129580 inSubset NCIT_C63923 @default.
- NCIT_C129580 type Class @default.
- NCIT_C129580 isDefinedBy ncit.owl @default.
- NCIT_C129580 label "Chk1 Inhibitor SRA737" @default.
- NCIT_C129580 subClassOf NCIT_C129580 @default.
- NCIT_C129580 subClassOf NCIT_C129824 @default.
- NCIT_C129580 subClassOf NCIT_C129825 @default.
- NCIT_C129580 subClassOf NCIT_C1404 @default.
- NCIT_C129580 subClassOf NCIT_C155927 @default.
- NCIT_C129580 subClassOf NCIT_C1908 @default.
- NCIT_C129580 subClassOf NCIT_C1909 @default.
- NCIT_C129580 subClassOf NCIT_C2189 @default.
- NCIT_C129580 subClassOf NCIT_C274 @default.
- NCIT_C129580 subClassOf NCIT_C471 @default.
- NCIT_C129580 subClassOf NCIT_C61074 @default.