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- NCIT_C129593 IAO_0000115 "A preparation of autologous human peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding for a T-cell chimeric antigen receptor (CAR) gene specific for the human cluster of differentiation 70 (CD70), with potential immunostimulatory and antineoplastic activities. Autologous PBLs from a patient with CD70-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for CD70. After expansion in culture and reintroduction into the patient, anti-hCD70-CAR retroviral vector-transduced autologous PBLs bind to the CD70 antigen on tumor cell surfaces; subsequently, CD70-expressing tumor cells are lysed. CD70, the ligand for the costimulatory receptor CD27, is overexpressed on the surfaces of various cancer cell types." @default.
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- NCIT_C129593 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129593 NCIT_P107 "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs" @default.
- NCIT_C129593 NCIT_P108 "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs" @default.
- NCIT_C129593 NCIT_P208 "CL512669" @default.
- NCIT_C129593 NCIT_P322 "CTRP" @default.
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- NCIT_C129593 normalizedInformationContent "100" @default.
- NCIT_C129593 referenceCount "1" @default.
- NCIT_C129593 hasExactSynonym "Anti-hCD70 Autologous CAR-transduced T Cells" @default.
- NCIT_C129593 hasExactSynonym "Anti-hCD70 CAR autologous PBLs" @default.
- NCIT_C129593 hasExactSynonym "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs" @default.
- NCIT_C129593 hasExactSynonym "Anti-hCD70-CAR Retroviral Vector-transduced Autologous Peripheral Blood Lymphocytes" @default.
- NCIT_C129593 inSubset NCIT_C116977 @default.
- NCIT_C129593 inSubset NCIT_C116978 @default.
- NCIT_C129593 inSubset NCIT_C128784 @default.
- NCIT_C129593 inSubset NCIT_C176424 @default.
- NCIT_C129593 type Class @default.
- NCIT_C129593 isDefinedBy ncit.owl @default.
- NCIT_C129593 label "Anti-hCD70-CAR Retroviral Vector-transduced Autologous PBLs" @default.
- NCIT_C129593 subClassOf NCIT_C129593 @default.
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- NCIT_C129593 subClassOf NCIT_C28681 @default.
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- NCIT_C129593 subClassOf NCIT_C308 @default.