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- NCIT_C129594 IAO_0000115 "An orally bioavailable small molecule inhibitor of the immune checkpoint regulatory proteins programmed cell death ligand-1 (PD-L1; B7-H1; CD274), PD-L2, and V-domain immunoglobulin (Ig) suppressor of T-cell activation (VISTA; programmed death 1 homolog; PD1H; PD-1H), with potential negative immune checkpoint regulatory and antineoplastic activities. Upon oral administration, PD-L1/PD-L2/VISTA antagonist CA-170 targets and binds to PD-L1, PD-L2 and VISTA. This inhibits PD-L1/PD-L2/VISTA-mediated signaling, abrogates the PD-L1-, PD-L2- and VISTA-induced suppression of T-lymphocyte immune responses, enhances cytotoxic T-cell proliferation and activation against tumor cells, increases cytokine production by T-cells, and inhibits tumor cell growth. PD-L1, PD-L2 and VISTA, negative checkpoint molecules of immune activation, play key roles in the suppression of T-cell functions." @default.
- NCIT_C129594 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129594 NCIT_A7 NCIT_C120581 @default.
- NCIT_C129594 NCIT_A7 NCIT_C45438 @default.
- NCIT_C129594 NCIT_A7 NCIT_C96024 @default.
- NCIT_C129594 NCIT_NHC0 "C129594" @default.
- NCIT_C129594 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129594 NCIT_P107 "PD-L1/PD-L2/VISTA Antagonist CA-170" @default.
- NCIT_C129594 NCIT_P108 "PD-L1/PD-L2/VISTA Antagonist CA-170" @default.
- NCIT_C129594 NCIT_P208 "CL512601" @default.
- NCIT_C129594 NCIT_P210 "1673534-76-3" @default.
- NCIT_C129594 NCIT_P319 "646MN6KQ16" @default.
- NCIT_C129594 NCIT_P322 "CTRP" @default.
- NCIT_C129594 NCIT_P322 "FDA" @default.
- NCIT_C129594 NCIT_P322 "GDC" @default.
- NCIT_C129594 NCIT_P329 "783861" @default.
- NCIT_C129594 NCIT_P330 "783861" @default.
- NCIT_C129594 NCIT_P375 "PD-L1/PD-L2/VISTA Antagonist CA-170" @default.
- NCIT_C129594 NCIT_P399 "783861" @default.
- NCIT_C129594 normalizedInformationContent "100" @default.
- NCIT_C129594 referenceCount "1" @default.
- NCIT_C129594 hasExactSynonym "AUPM 170" @default.
- NCIT_C129594 hasExactSynonym "Aurigene 1" @default.
- NCIT_C129594 hasExactSynonym "CA-170" @default.
- NCIT_C129594 hasExactSynonym "PD-L1/PD-L2/VISTA Antagonist CA-170" @default.
- NCIT_C129594 hasExactSynonym "PD-L1/PD-L2/VISTA Checkpoint Antagonist CA-170" @default.
- NCIT_C129594 inSubset NCIT_C116977 @default.
- NCIT_C129594 inSubset NCIT_C116978 @default.
- NCIT_C129594 inSubset NCIT_C128784 @default.
- NCIT_C129594 inSubset NCIT_C157711 @default.
- NCIT_C129594 inSubset NCIT_C157712 @default.
- NCIT_C129594 inSubset NCIT_C176424 @default.
- NCIT_C129594 inSubset NCIT_C177537 @default.
- NCIT_C129594 inSubset NCIT_C63923 @default.
- NCIT_C129594 type Class @default.
- NCIT_C129594 isDefinedBy ncit.owl @default.
- NCIT_C129594 label "PD-L1/PD-L2/VISTA Antagonist CA-170" @default.
- NCIT_C129594 subClassOf NCIT_C129594 @default.
- NCIT_C129594 subClassOf NCIT_C141144 @default.
- NCIT_C129594 subClassOf NCIT_C143250 @default.
- NCIT_C129594 subClassOf NCIT_C156893 @default.
- NCIT_C129594 subClassOf NCIT_C163758 @default.
- NCIT_C129594 subClassOf NCIT_C1908 @default.
- NCIT_C129594 subClassOf NCIT_C1909 @default.
- NCIT_C129594 subClassOf NCIT_C191689 @default.
- NCIT_C129594 subClassOf NCIT_C191691 @default.
- NCIT_C129594 subClassOf NCIT_C199655 @default.
- NCIT_C129594 subClassOf NCIT_C274 @default.
- NCIT_C129594 subClassOf NCIT_C308 @default.