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- NCIT_C129595 IAO_0000115 "A nutritional supplement composed of an aqueous extract derived from the leaves of the tropical fern belonging to the Polypodiaceae family, Polypodium leucotomos (PL; Phlebodium aureum), with potential photoprotective, skin protective, anti-inflammatory, immunomodulating and antioxidant activities. This extract contains many phenolic compounds, such as ferulic, caffeic, coumaric and vanillic acid, which are mainly responsible for this extract's effects. Upon administration, Polypodium leucotomos extract (PLE) exerts antioxidant activity by scavenging free radicals and inhibiting the generation and release of reactive oxygen species (ROS), thereby preventing ultraviolet (UV)-induced as well as ROS-induced DNA damage. In addition, the chemicals in this extract protect antioxidant enzymes and modulate expression of cancer and inflammation-related genes, including the induction of the expression of tumor suppressor genes and the inhibition of the expression of pro-inflammatory cytokines and inflammatory enzymes, thereby inhibiting the activation of signal transduction pathways involved in carcinogenesis and inflammation, respectively. PLE also stimulates tissue inhibitors of metalloproteinases (TIMPs) and inhibits matrix metalloproteinases (MMPs)." @default.
- NCIT_C129595 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129595 NCIT_NHC0 "C129595" @default.
- NCIT_C129595 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129595 NCIT_P108 "Polypodium leucotomos Extract" @default.
- NCIT_C129595 NCIT_P207 "C1614561" @default.
- NCIT_C129595 NCIT_P322 "GDC" @default.
- NCIT_C129595 NCIT_P329 "783987" @default.
- NCIT_C129595 NCIT_P330 "783987" @default.
- NCIT_C129595 NCIT_P375 "Polypodium leucotomos Extract" @default.
- NCIT_C129595 NCIT_P399 "783987" @default.
- NCIT_C129595 normalizedInformationContent "100" @default.
- NCIT_C129595 referenceCount "1" @default.
- NCIT_C129595 hasExactSynonym "Fernblock" @default.
- NCIT_C129595 hasExactSynonym "PL Extract" @default.
- NCIT_C129595 hasExactSynonym "PLE" @default.
- NCIT_C129595 hasExactSynonym "Polypodium leucotomos Extract" @default.
- NCIT_C129595 inSubset NCIT_C128784 @default.
- NCIT_C129595 inSubset NCIT_C157711 @default.
- NCIT_C129595 inSubset NCIT_C157712 @default.
- NCIT_C129595 inSubset NCIT_C176424 @default.
- NCIT_C129595 inSubset NCIT_C177537 @default.
- NCIT_C129595 type Class @default.
- NCIT_C129595 isDefinedBy ncit.owl @default.
- NCIT_C129595 label "Polypodium leucotomos Extract" @default.
- NCIT_C129595 subClassOf NCIT_C129595 @default.
- NCIT_C129595 subClassOf NCIT_C1505 @default.
- NCIT_C129595 subClassOf NCIT_C1908 @default.