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- NCIT_C129688 IAO_0000115 "An inhibitor of colony stimulating factor 1 receptor (CSF1R; CSF-1R), with potential antineoplastic activity. Upon administration, CSF1R inhibitor PLX73086 targets and binds to CSF1R, thereby blocking CSF1R activation and CSF1R-mediated signaling. This inhibits the activity of tumor-associated macrophages (TAMs) in the tumor tissue and prevents TAM-related tumor cell growth. CSF1R, also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface receptor for its ligand colony stimulating factor 1 (CSF1) and plays major roles in tumor cell proliferation and metastasis." @default.
- NCIT_C129688 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129688 NCIT_A7 NCIT_C17392 @default.
- NCIT_C129688 NCIT_NHC0 "C129688" @default.
- NCIT_C129688 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129688 NCIT_P107 "CSF1R Inhibitor PLX73086" @default.
- NCIT_C129688 NCIT_P108 "CSF1R Inhibitor PLX73086" @default.
- NCIT_C129688 NCIT_P208 "CL507868" @default.
- NCIT_C129688 NCIT_P322 "CTRP" @default.
- NCIT_C129688 NCIT_P322 "GDC" @default.
- NCIT_C129688 NCIT_P375 "CSF1R Inhibitor PLX73086" @default.
- NCIT_C129688 normalizedInformationContent "100" @default.
- NCIT_C129688 referenceCount "1" @default.
- NCIT_C129688 hasExactSynonym "AC-708" @default.
- NCIT_C129688 hasExactSynonym "AC708" @default.
- NCIT_C129688 hasExactSynonym "CSF1R Inhibitor PLX73086" @default.
- NCIT_C129688 hasExactSynonym "PLX7 3086" @default.
- NCIT_C129688 hasExactSynonym "PLX73086" @default.
- NCIT_C129688 inSubset NCIT_C116977 @default.
- NCIT_C129688 inSubset NCIT_C116978 @default.
- NCIT_C129688 inSubset NCIT_C128784 @default.
- NCIT_C129688 inSubset NCIT_C157711 @default.
- NCIT_C129688 inSubset NCIT_C157712 @default.
- NCIT_C129688 inSubset NCIT_C177537 @default.
- NCIT_C129688 type Class @default.
- NCIT_C129688 isDefinedBy ncit.owl @default.
- NCIT_C129688 label "CSF1R Inhibitor PLX73086" @default.
- NCIT_C129688 subClassOf NCIT_C129688 @default.
- NCIT_C129688 subClassOf NCIT_C129820 @default.
- NCIT_C129688 subClassOf NCIT_C1404 @default.
- NCIT_C129688 subClassOf NCIT_C163758 @default.
- NCIT_C129688 subClassOf NCIT_C1908 @default.
- NCIT_C129688 subClassOf NCIT_C1909 @default.
- NCIT_C129688 subClassOf NCIT_C1967 @default.
- NCIT_C129688 subClassOf NCIT_C198643 @default.
- NCIT_C129688 subClassOf NCIT_C198646 @default.
- NCIT_C129688 subClassOf NCIT_C274 @default.
- NCIT_C129688 subClassOf NCIT_C308 @default.
- NCIT_C129688 subClassOf NCIT_C471 @default.