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- NCIT_C129710 IAO_0000115 "An orally bioavailable, selective inhibitor of Bruton's tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, M7583 targets and covalently binds to BTK, thereby preventing its activity. This leads to an inhibition of B cell receptor (BCR) signaling and inhibits cell proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival." @default.
- NCIT_C129710 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129710 NCIT_A7 NCIT_C75017 @default.
- NCIT_C129710 NCIT_NHC0 "C129710" @default.
- NCIT_C129710 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129710 NCIT_P108 "BTK Inhibitor M7583" @default.
- NCIT_C129710 NCIT_P208 "CL512935" @default.
- NCIT_C129710 NCIT_P322 "GDC" @default.
- NCIT_C129710 NCIT_P329 "784381" @default.
- NCIT_C129710 NCIT_P330 "784381" @default.
- NCIT_C129710 NCIT_P375 "BTK Inhibitor M7583" @default.
- NCIT_C129710 NCIT_P399 "784381" @default.
- NCIT_C129710 normalizedInformationContent "100" @default.
- NCIT_C129710 referenceCount "1" @default.
- NCIT_C129710 hasExactSynonym "BTK Inhibitor M7583" @default.
- NCIT_C129710 hasExactSynonym "Bruton's Tyrosine Kinase Inhibitor M7583" @default.
- NCIT_C129710 hasExactSynonym "M7583" @default.
- NCIT_C129710 inSubset NCIT_C128784 @default.
- NCIT_C129710 inSubset NCIT_C157711 @default.
- NCIT_C129710 inSubset NCIT_C157712 @default.
- NCIT_C129710 inSubset NCIT_C176424 @default.
- NCIT_C129710 inSubset NCIT_C177537 @default.
- NCIT_C129710 type Class @default.
- NCIT_C129710 isDefinedBy ncit.owl @default.
- NCIT_C129710 label "BTK Inhibitor M7583" @default.
- NCIT_C129710 subClassOf NCIT_C124801 @default.
- NCIT_C129710 subClassOf NCIT_C129710 @default.
- NCIT_C129710 subClassOf NCIT_C129824 @default.
- NCIT_C129710 subClassOf NCIT_C129825 @default.
- NCIT_C129710 subClassOf NCIT_C1404 @default.
- NCIT_C129710 subClassOf NCIT_C163758 @default.
- NCIT_C129710 subClassOf NCIT_C163774 @default.
- NCIT_C129710 subClassOf NCIT_C1908 @default.
- NCIT_C129710 subClassOf NCIT_C1909 @default.
- NCIT_C129710 subClassOf NCIT_C1967 @default.
- NCIT_C129710 subClassOf NCIT_C2189 @default.
- NCIT_C129710 subClassOf NCIT_C274 @default.
- NCIT_C129710 subClassOf NCIT_C471 @default.