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- NCIT_C129712 IAO_0000115 "A calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids that can be used to treat secondary hyperparathyroidism (sHPT) in hemodialysis patients with chronic kidney disease (CKD). Upon intravenous administration, etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis." @default.
- NCIT_C129712 NCIT_NHC0 "C129712" @default.
- NCIT_C129712 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129712 NCIT_P108 "Etelcalcetide" @default.
- NCIT_C129712 NCIT_P207 "C3712398" @default.
- NCIT_C129712 NCIT_P210 "1262780-97-1" @default.
- NCIT_C129712 NCIT_P319 "60ME133FJB" @default.
- NCIT_C129712 NCIT_P322 "FDA" @default.
- NCIT_C129712 NCIT_P329 "784383" @default.
- NCIT_C129712 NCIT_P330 "784383" @default.
- NCIT_C129712 NCIT_P399 "784383" @default.
- NCIT_C129712 normalizedInformationContent "100" @default.
- NCIT_C129712 referenceCount "1" @default.
- NCIT_C129712 hasExactSynonym "AMG 416" @default.
- NCIT_C129712 hasExactSynonym "AMG416" @default.
- NCIT_C129712 hasExactSynonym "ETELCALCETIDE" @default.
- NCIT_C129712 hasExactSynonym "Etelcalcetide" @default.
- NCIT_C129712 hasExactSynonym "KAI 4169" @default.
- NCIT_C129712 hasExactSynonym "KAI-4169" @default.
- NCIT_C129712 hasExactSynonym "KAI4169" @default.
- NCIT_C129712 hasExactSynonym "N-acetyl-D-cysteinyl-S-(L-cysteine disulfide)-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide" @default.
- NCIT_C129712 hasExactSynonym "Parsabiv" @default.
- NCIT_C129712 hasExactSynonym "Velcalcetide" @default.
- NCIT_C129712 inSubset NCIT_C176424 @default.
- NCIT_C129712 inSubset NCIT_C63923 @default.
- NCIT_C129712 type Class @default.
- NCIT_C129712 isDefinedBy ncit.owl @default.
- NCIT_C129712 label "Etelcalcetide" @default.
- NCIT_C129712 subClassOf NCIT_C129712 @default.
- NCIT_C129712 subClassOf NCIT_C1908 @default.
- NCIT_C129712 subClassOf NCIT_C1909 @default.
- NCIT_C129712 subClassOf NCIT_C78275 @default.