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- NCIT_C129876 IAO_0000115 "An agonistic humanized monoclonal antibody that recognizes inducible T-cell co-stimulator (ICOS; CD278), with potential antineoplastic activity. Upon administration, anti-ICOS agonist monoclonal antibody JTX-2011 targets and binds to ICOS expressed on certain T-cells. This stimulates ICOS-mediated signaling, induces proliferation of ICOS-positive T-cells, enhances cytotoxic T-lymphocyte (CTL) survival and augments the CTL-mediated immune response against tumor cells. ICOS, a T-cell specific, CD28-superfamily co-stimulatory molecule and immune checkpoint protein, is normally expressed on certain activated T-cells and plays a key role in the proliferation and activation of T-cells." @default.
- NCIT_C129876 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129876 NCIT_A7 NCIT_C94803 @default.
- NCIT_C129876 NCIT_NHC0 "C129876" @default.
- NCIT_C129876 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C129876 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129876 NCIT_P107 "Vopratelimab" @default.
- NCIT_C129876 NCIT_P108 "Vopratelimab" @default.
- NCIT_C129876 NCIT_P208 "CL512902" @default.
- NCIT_C129876 NCIT_P210 "2039148-04-2" @default.
- NCIT_C129876 NCIT_P319 "QXN20J93AH" @default.
- NCIT_C129876 NCIT_P322 "CTRP" @default.
- NCIT_C129876 NCIT_P322 "FDA" @default.
- NCIT_C129876 NCIT_P322 "GDC" @default.
- NCIT_C129876 NCIT_P329 "784959" @default.
- NCIT_C129876 NCIT_P330 "784959" @default.
- NCIT_C129876 NCIT_P375 "Vopratelimab" @default.
- NCIT_C129876 NCIT_P399 "784959" @default.
- NCIT_C129876 NCIT_R124 NCIT_C17710 @default.
- NCIT_C129876 NCIT_R124 NCIT_C17828 @default.
- NCIT_C129876 NCIT_R124 NCIT_C18219 @default.
- NCIT_C129876 NCIT_R124 NCIT_C19986 @default.
- NCIT_C129876 NCIT_R124 NCIT_C40474 @default.
- NCIT_C129876 normalizedInformationContent "100" @default.
- NCIT_C129876 referenceCount "1" @default.
- NCIT_C129876 hasExactSynonym "Anti-ICOS Agonist MAb JTX-2011" @default.
- NCIT_C129876 hasExactSynonym "Anti-ICOS Agonist Monoclonal Antibody JTX-2011" @default.
- NCIT_C129876 hasExactSynonym "ICOS Agonist Monoclonal Antibody JTX-2011" @default.
- NCIT_C129876 hasExactSynonym "JTX-2011" @default.
- NCIT_C129876 hasExactSynonym "VOPRATELIMAB" @default.
- NCIT_C129876 hasExactSynonym "Vopratelimab" @default.
- NCIT_C129876 inSubset NCIT_C116977 @default.
- NCIT_C129876 inSubset NCIT_C116978 @default.
- NCIT_C129876 inSubset NCIT_C128784 @default.
- NCIT_C129876 inSubset NCIT_C157711 @default.
- NCIT_C129876 inSubset NCIT_C157712 @default.
- NCIT_C129876 inSubset NCIT_C176424 @default.
- NCIT_C129876 inSubset NCIT_C177537 @default.
- NCIT_C129876 inSubset NCIT_C63923 @default.
- NCIT_C129876 type Class @default.
- NCIT_C129876 isDefinedBy ncit.owl @default.
- NCIT_C129876 label "Vopratelimab" @default.
- NCIT_C129876 subClassOf NCIT_C129821 @default.
- NCIT_C129876 subClassOf NCIT_C129822 @default.
- NCIT_C129876 subClassOf NCIT_C129876 @default.
- NCIT_C129876 subClassOf NCIT_C141144 @default.
- NCIT_C129876 subClassOf NCIT_C141145 @default.
- NCIT_C129876 subClassOf NCIT_C1908 @default.
- NCIT_C129876 subClassOf NCIT_C1909 @default.
- NCIT_C129876 subClassOf NCIT_C20401 @default.
- NCIT_C129876 subClassOf NCIT_C274 @default.
- NCIT_C129876 subClassOf NCIT_C307 @default.
- NCIT_C129876 subClassOf NCIT_C308 @default.