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- NCIT_C129937 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed against the extracellular domain of receptor-type tyrosine-protein kinase FLT3 (FLT-3; FMS-like tyrosine kinase 3; CD135; fetal-liver kinase 2; FLK2) and conjugated, via an oxime linker and the site-directed non-natural amino acid linker para-acetyl-phenylalanine (pAcF), to a microtubule-disrupting cytotoxic agent, with potential antineoplastic activity. Upon administration of ADC AGS62P1, the antibody moiety targets and binds to FLT3. Upon antibody/antigen binding and internalization, the microtubule-targeting agent binds to and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis. The site-specific conjugation of the cytotoxic agent to the antibody, through pAcF, improves the biophysical properties of AGS62P1, increases payload distribution and stability, and optimizes its efficacy. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage, acute lymphoblastic leukemias and acute myeloid leukemias." @default.
- NCIT_C129937 NCIT_A32 NCIT_C1909 @default.
- NCIT_C129937 NCIT_A7 NCIT_C26202 @default.
- NCIT_C129937 NCIT_NHC0 "C129937" @default.
- NCIT_C129937 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C129937 NCIT_P107 "Anti-FLT3 Antibody-drug Conjugate AGS62P1" @default.
- NCIT_C129937 NCIT_P108 "Anti-FLT3 Antibody-drug Conjugate AGS62P1" @default.
- NCIT_C129937 NCIT_P208 "CL513016" @default.
- NCIT_C129937 NCIT_P319 "37I4D4Q7S2" @default.
- NCIT_C129937 NCIT_P322 "CTRP" @default.
- NCIT_C129937 NCIT_P322 "FDA" @default.
- NCIT_C129937 NCIT_P322 "GDC" @default.
- NCIT_C129937 NCIT_P329 "785317" @default.
- NCIT_C129937 NCIT_P330 "785317" @default.
- NCIT_C129937 NCIT_P375 "Anti-FLT3 Antibody-drug Conjugate AGS62P1" @default.
- NCIT_C129937 NCIT_P399 "785317" @default.
- NCIT_C129937 normalizedInformationContent "100" @default.
- NCIT_C129937 referenceCount "1" @default.
- NCIT_C129937 hasExactSynonym "ADC AGS62P1" @default.
- NCIT_C129937 hasExactSynonym "AGS62P1" @default.
- NCIT_C129937 hasExactSynonym "Anti-FLT3 Antibody-drug Conjugate AGS62P1" @default.
- NCIT_C129937 inSubset NCIT_C116977 @default.
- NCIT_C129937 inSubset NCIT_C116978 @default.
- NCIT_C129937 inSubset NCIT_C128784 @default.
- NCIT_C129937 inSubset NCIT_C157711 @default.
- NCIT_C129937 inSubset NCIT_C157712 @default.
- NCIT_C129937 inSubset NCIT_C176424 @default.
- NCIT_C129937 inSubset NCIT_C177537 @default.
- NCIT_C129937 inSubset NCIT_C63923 @default.
- NCIT_C129937 type Class @default.
- NCIT_C129937 isDefinedBy ncit.owl @default.
- NCIT_C129937 label "Anti-FLT3 Antibody-drug Conjugate AGS62P1" @default.
- NCIT_C129937 subClassOf NCIT_C129821 @default.
- NCIT_C129937 subClassOf NCIT_C129823 @default.
- NCIT_C129937 subClassOf NCIT_C129937 @default.
- NCIT_C129937 subClassOf NCIT_C1512 @default.
- NCIT_C129937 subClassOf NCIT_C163758 @default.
- NCIT_C129937 subClassOf NCIT_C163790 @default.
- NCIT_C129937 subClassOf NCIT_C1908 @default.
- NCIT_C129937 subClassOf NCIT_C1909 @default.
- NCIT_C129937 subClassOf NCIT_C274 @default.
- NCIT_C129937 subClassOf NCIT_C307 @default.
- NCIT_C129937 subClassOf NCIT_C308 @default.