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- NCIT_C1300 IAO_0000115 "A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis. This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)" @default.
- NCIT_C1300 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1300 NCIT_NHC0 "C1300" @default.
- NCIT_C1300 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1300 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1300 NCIT_P107 "Dolastatin 10" @default.
- NCIT_C1300 NCIT_P108 "Dolastatin 10" @default.
- NCIT_C1300 NCIT_P175 "376128" @default.
- NCIT_C1300 NCIT_P207 "C0082338" @default.
- NCIT_C1300 NCIT_P210 "110417-88-4" @default.
- NCIT_C1300 NCIT_P319 "EI946JT51X" @default.
- NCIT_C1300 NCIT_P322 "CTRP" @default.
- NCIT_C1300 NCIT_P322 "FDA" @default.
- NCIT_C1300 NCIT_P322 "GDC" @default.
- NCIT_C1300 NCIT_P325 "A substance being studied in the treatment of cancer. It binds to a protein that cells need to divide and it may kill cancer cells. Dolastatin 10 comes from a marine organism. It is a type of mitotic inhibitor." @default.
- NCIT_C1300 NCIT_P329 "42316" @default.
- NCIT_C1300 NCIT_P330 "42316" @default.
- NCIT_C1300 NCIT_P366 "Dolastatin_10" @default.
- NCIT_C1300 NCIT_P375 "Dolastatin 10" @default.
- NCIT_C1300 NCIT_P399 "42316" @default.
- NCIT_C1300 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C1300 NCIT_R125 NCIT_C16397 @default.
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- NCIT_C1300 NCIT_R125 NCIT_C21102 @default.
- NCIT_C1300 NCIT_R125 NCIT_C40715 @default.
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- NCIT_C1300 NCIT_R125 NCIT_C41515 @default.
- NCIT_C1300 NCIT_R125 NCIT_C51037 @default.
- NCIT_C1300 NCIT_R146 NCIT_C16492 @default.
- NCIT_C1300 NCIT_R146 NCIT_C17021 @default.
- NCIT_C1300 NCIT_R146 NCIT_C17219 @default.
- NCIT_C1300 NCIT_R146 NCIT_C18073 @default.
- NCIT_C1300 NCIT_R146 NCIT_C20027 @default.
- NCIT_C1300 NCIT_R146 NCIT_C26548 @default.
- NCIT_C1300 normalizedInformationContent "100" @default.
- NCIT_C1300 referenceCount "1" @default.
- NCIT_C1300 hasExactSynonym "B720389K560" @default.
- NCIT_C1300 hasExactSynonym "DOLASTATIN 10" @default.
- NCIT_C1300 hasExactSynonym "Dolastatin 10" @default.
- NCIT_C1300 hasExactSynonym "Dolastatin-10" @default.
- NCIT_C1300 hasExactSynonym "L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]" @default.
- NCIT_C1300 hasExactSynonym "dolastatin 10" @default.
- NCIT_C1300 inSubset NCIT_C116977 @default.
- NCIT_C1300 inSubset NCIT_C116978 @default.
- NCIT_C1300 inSubset NCIT_C128784 @default.
- NCIT_C1300 inSubset NCIT_C157711 @default.
- NCIT_C1300 inSubset NCIT_C157712 @default.
- NCIT_C1300 inSubset NCIT_C176424 @default.
- NCIT_C1300 inSubset NCIT_C177537 @default.
- NCIT_C1300 inSubset NCIT_C63923 @default.
- NCIT_C1300 type Class @default.
- NCIT_C1300 isDefinedBy ncit.owl @default.
- NCIT_C1300 label "Dolastatin 10" @default.
- NCIT_C1300 subClassOf B1a09a7bfddbfc697d99780060f4e927b @default.
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- NCIT_C1300 subClassOf NCIT_C200714 @default.
- NCIT_C1300 subClassOf NCIT_C232 @default.
- NCIT_C1300 subClassOf NCIT_C25974 @default.
- NCIT_C1300 subClassOf NCIT_C273 @default.
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- NCIT_C1300 subClassOf NCIT_C718 @default.
- NCIT_C1300 subClassOf NCIT_C735 @default.