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- NCIT_C130014 IAO_0000115 "A radiopharmaceutical tracer containing the anti-diabetic agent metformin, a biguanide and hydrophilic organic cation, and labeled with carbon 11 (11C), used to measure metformin uptake by cancer cells using positron emission tomography (PET). Upon administration of carbon C 11 metformin, the metformin moiety targets and binds to cancer cells; in turn, the compound is taken up by cancer cells. Upon PET, metformin distribution into cancer cells can be visualized, which allows for a prediction of the anti-cancer efficacy of metformin, based on tumor cell uptake. Metformin transport, such as uptake into cancer cells, appears to be correlated with the expression of organic cation transporters (OCT) 1-3, multidrug and toxin extrusion (MATE) 1 and 2, and plasma membrane monoamine transporter (PMAT). OCTs, MATEs and PMAT play a key role in the distribution and excretion of organic cationic compounds." @default.
- NCIT_C130014 NCIT_NHC0 "C130014" @default.
- NCIT_C130014 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C130014 NCIT_P108 "Carbon C 11 Metformin" @default.
- NCIT_C130014 NCIT_P208 "CL514004" @default.
- NCIT_C130014 NCIT_P319 "6AI63CHT0T" @default.
- NCIT_C130014 NCIT_P322 "FDA" @default.
- NCIT_C130014 NCIT_P329 "784870" @default.
- NCIT_C130014 NCIT_P330 "784870" @default.
- NCIT_C130014 NCIT_P399 "784870" @default.
- NCIT_C130014 normalizedInformationContent "100" @default.
- NCIT_C130014 referenceCount "1" @default.
- NCIT_C130014 hasExactSynonym "11C-metformin" @default.
- NCIT_C130014 hasExactSynonym "Carbon C 11 Metformin" @default.
- NCIT_C130014 hasExactSynonym "Carbon-11 Metformin" @default.
- NCIT_C130014 hasExactSynonym "METFORMIN C-11" @default.
- NCIT_C130014 hasExactSynonym "[11C]-metformin" @default.
- NCIT_C130014 inSubset NCIT_C176424 @default.
- NCIT_C130014 inSubset NCIT_C63923 @default.
- NCIT_C130014 type Class @default.
- NCIT_C130014 isDefinedBy ncit.owl @default.
- NCIT_C130014 label "Carbon C 11 Metformin" @default.
- NCIT_C130014 subClassOf NCIT_C130014 @default.
- NCIT_C130014 subClassOf NCIT_C1446 @default.
- NCIT_C130014 subClassOf NCIT_C1908 @default.
- NCIT_C130014 subClassOf NCIT_C1909 @default.
- NCIT_C130014 subClassOf NCIT_C2124 @default.