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- NCIT_C131018 IAO_0000115 "A recombinant form of human bone morphogenetic protein 4 (rhBMP4; rhBMP-4), with potential antineoplastic activity. Upon administration, rhBMP4 binds to BMP receptors (BMPRs) and activates BMP-mediated signal transduction pathways. This may lead to the transcription of BMP4-target genes and to inhibition of the proliferation of certain tumor cell types. Additionally, rhBMP4 binding promotes the differentiation of normal stem cells and decreases both differentiation and renewal of cancer stem cells (CSCs). BMP4, an extracellular signaling molecule belonging to the transforming growth factor beta (TGFb) superfamily, plays a key role in bone formation. It also plays a role in the pathogenesis of certain cancers; BMP4 suppresses growth of certain types of cancer cells, and is also able to induce migration, invasion, and epithelial-mesenchymal transition (EMT), which may promote cancer metastasis and progression." @default.
- NCIT_C131018 NCIT_NHC0 "C131018" @default.
- NCIT_C131018 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131018 NCIT_P108 "Recombinant Human Bone Morphogenetic Protein 4" @default.
- NCIT_C131018 NCIT_P208 "CL514072" @default.
- NCIT_C131018 NCIT_P319 "08RQ4CQ601" @default.
- NCIT_C131018 NCIT_P322 "FDA" @default.
- NCIT_C131018 NCIT_P329 "785045" @default.
- NCIT_C131018 NCIT_P330 "785045" @default.
- NCIT_C131018 NCIT_P399 "785045" @default.
- NCIT_C131018 normalizedInformationContent "100" @default.
- NCIT_C131018 referenceCount "1" @default.
- NCIT_C131018 hasExactSynonym "HUMAN RECOMBINANT BONE MORPHOGENETIC PROTEIN 4" @default.
- NCIT_C131018 hasExactSynonym "Recombinant Human BMP4" @default.
- NCIT_C131018 hasExactSynonym "Recombinant Human Bone Morphogenetic Protein 4" @default.
- NCIT_C131018 hasExactSynonym "hrBMP-4" @default.
- NCIT_C131018 hasExactSynonym "hrBMP4" @default.
- NCIT_C131018 inSubset NCIT_C176424 @default.
- NCIT_C131018 inSubset NCIT_C63923 @default.
- NCIT_C131018 type Class @default.
- NCIT_C131018 isDefinedBy ncit.owl @default.
- NCIT_C131018 label "Recombinant Human Bone Morphogenetic Protein 4" @default.
- NCIT_C131018 subClassOf NCIT_C129821 @default.
- NCIT_C131018 subClassOf NCIT_C131018 @default.
- NCIT_C131018 subClassOf NCIT_C1908 @default.
- NCIT_C131018 subClassOf NCIT_C1909 @default.
- NCIT_C131018 subClassOf NCIT_C274 @default.
- NCIT_C131018 subClassOf NCIT_C307 @default.