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- NCIT_C131019 IAO_0000115 "A recombinant form of the endogenous cytokine interleukin-2 (IL-2) conjugated to six releasable polyethylene glycol (PEG) chains, with potential immunostimulating activity. Upon administration of bempegaldesleukin, the IL-2 moiety binds to the IL-2 receptor beta subunit (IL2Rb; IL2Rbeta; CD122). The binding of IL-2 to IL2Rb activates IL2Rb-mediated signaling, which activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). The specific induction of T-cell-mediated cytotoxic immune responses against tumor cells primarily causes tumor cell destruction. IL2Rb plays a key role in the proliferation and activation of effector T-cells. PEG conjugation prevents IL-2 binding to the IL2Ralpha subunit (IL2Ra) because signaling through IL2Ra activates CD4-positive regulatory, immunosuppressive T-cells (Tregs), which would suppress tumor cell killing." @default.
- NCIT_C131019 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131019 NCIT_NHC0 "C131019" @default.
- NCIT_C131019 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C131019 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C131019 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131019 NCIT_P107 "Bempegaldesleukin" @default.
- NCIT_C131019 NCIT_P108 "Bempegaldesleukin" @default.
- NCIT_C131019 NCIT_P208 "CL513468" @default.
- NCIT_C131019 NCIT_P210 "1939126-74-5" @default.
- NCIT_C131019 NCIT_P319 "BNO1JG5MZC" @default.
- NCIT_C131019 NCIT_P322 "CTRP" @default.
- NCIT_C131019 NCIT_P322 "FDA" @default.
- NCIT_C131019 NCIT_P322 "GDC" @default.
- NCIT_C131019 NCIT_P329 "785056" @default.
- NCIT_C131019 NCIT_P330 "785056" @default.
- NCIT_C131019 NCIT_P375 "Bempegaldesleukin" @default.
- NCIT_C131019 NCIT_P399 "785056" @default.
- NCIT_C131019 NCIT_R124 NCIT_C17828 @default.
- NCIT_C131019 NCIT_R124 NCIT_C18992 @default.
- NCIT_C131019 NCIT_R124 NCIT_C19143 @default.
- NCIT_C131019 NCIT_R124 NCIT_C21124 @default.
- NCIT_C131019 NCIT_R124 NCIT_C40702 @default.
- NCIT_C131019 NCIT_R124 NCIT_C45547 @default.
- NCIT_C131019 NCIT_R125 NCIT_C16395 @default.
- NCIT_C131019 NCIT_R125 NCIT_C17710 @default.
- NCIT_C131019 NCIT_R125 NCIT_C17828 @default.
- NCIT_C131019 NCIT_R125 NCIT_C17937 @default.
- NCIT_C131019 NCIT_R125 NCIT_C18081 @default.
- NCIT_C131019 NCIT_R125 NCIT_C18095 @default.
- NCIT_C131019 NCIT_R125 NCIT_C18839 @default.
- NCIT_C131019 NCIT_R125 NCIT_C20480 @default.
- NCIT_C131019 NCIT_R125 NCIT_C20751 @default.
- NCIT_C131019 NCIT_R125 NCIT_C21049 @default.
- NCIT_C131019 NCIT_R125 NCIT_C21050 @default.
- NCIT_C131019 NCIT_R125 NCIT_C21124 @default.
- NCIT_C131019 NCIT_R125 NCIT_C26280 @default.
- NCIT_C131019 NCIT_R125 NCIT_C28498 @default.
- NCIT_C131019 NCIT_R125 NCIT_C40767 @default.
- NCIT_C131019 NCIT_R125 NCIT_C40833 @default.
- NCIT_C131019 NCIT_R125 NCIT_C40912 @default.
- NCIT_C131019 NCIT_R146 NCIT_C104679 @default.
- NCIT_C131019 NCIT_R146 NCIT_C21176 @default.
- NCIT_C131019 NCIT_R146 NCIT_C26548 @default.
- NCIT_C131019 normalizedInformationContent "100" @default.
- NCIT_C131019 referenceCount "1" @default.
- NCIT_C131019 hasExactSynonym "Aldesleukin Prodrug NKTR-214" @default.
- NCIT_C131019 hasExactSynonym "BEMPEGALDESLEUKIN" @default.
- NCIT_C131019 hasExactSynonym "Bempegaldesleukin" @default.
- NCIT_C131019 hasExactSynonym "NKTR-214" @default.
- NCIT_C131019 inSubset NCIT_C116977 @default.
- NCIT_C131019 inSubset NCIT_C116978 @default.
- NCIT_C131019 inSubset NCIT_C128784 @default.
- NCIT_C131019 inSubset NCIT_C157711 @default.
- NCIT_C131019 inSubset NCIT_C157712 @default.
- NCIT_C131019 inSubset NCIT_C176424 @default.
- NCIT_C131019 inSubset NCIT_C177537 @default.
- NCIT_C131019 inSubset NCIT_C63923 @default.
- NCIT_C131019 type Class @default.
- NCIT_C131019 isDefinedBy ncit.owl @default.
- NCIT_C131019 label "Bempegaldesleukin" @default.
- NCIT_C131019 subClassOf NCIT_C1283 @default.
- NCIT_C131019 subClassOf NCIT_C131019 @default.
- NCIT_C131019 subClassOf NCIT_C1908 @default.
- NCIT_C131019 subClassOf NCIT_C1909 @default.
- NCIT_C131019 subClassOf NCIT_C307 @default.
- NCIT_C131019 subClassOf NCIT_C308 @default.
- NCIT_C131019 subClassOf NCIT_C587 @default.
- NCIT_C131019 subClassOf NCIT_C593 @default.