Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C131174> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- NCIT_C131174 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of an engineered cysteine humanized monoclonal antibody (EC-mAb) targeting CD352 (SLAM family member 6; SLAM6) that is conjugated to the cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. Upon administration of anti-CD352 ADC SGN-CD352A, the antibody moiety targets the cell surface antigen CD352. Upon antibody/antigen binding, internalization, and lysosome uptake, the cytotoxic PBD moiety is released. In turn, the imine groups of the PBD moiety bind to the N2 positions of guanines on opposite strands of DNA. This induces DNA strand breaks, inhibits DNA replication, leads to G2/M cell cycle arrest, induces cell death, and inhibits the proliferation of CD352-overexpressing tumor cells. CD352, a tumor-associated antigen (TAA), is overexpressed on a variety of cancers. Cysteine engineering of the monoclonal antibody allows for a site-specific, stable conjugation and uniform loading of the PBD agent to the antibody." @default.
- NCIT_C131174 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131174 NCIT_A7 NCIT_C105057 @default.
- NCIT_C131174 NCIT_NHC0 "C131174" @default.
- NCIT_C131174 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131174 NCIT_P107 "Anti-CD352 Antibody-drug Conjugate SGN-CD352A" @default.
- NCIT_C131174 NCIT_P108 "Anti-CD352 Antibody-drug Conjugate SGN-CD352A" @default.
- NCIT_C131174 NCIT_P208 "CL513495" @default.
- NCIT_C131174 NCIT_P319 "ZX1I49XP7L" @default.
- NCIT_C131174 NCIT_P322 "CTRP" @default.
- NCIT_C131174 NCIT_P322 "FDA" @default.
- NCIT_C131174 NCIT_P322 "GDC" @default.
- NCIT_C131174 NCIT_P329 "785477" @default.
- NCIT_C131174 NCIT_P330 "785477" @default.
- NCIT_C131174 NCIT_P375 "Anti-CD352 Antibody-drug Conjugate SGN-CD352A" @default.
- NCIT_C131174 NCIT_P399 "785477" @default.
- NCIT_C131174 normalizedInformationContent "100" @default.
- NCIT_C131174 referenceCount "1" @default.
- NCIT_C131174 hasExactSynonym "ADC SGN-CD352A" @default.
- NCIT_C131174 hasExactSynonym "Anti-CD352 Antibody-drug Conjugate SGN-CD352A" @default.
- NCIT_C131174 hasExactSynonym "PBD Dimer ADC SGN-CD352A" @default.
- NCIT_C131174 hasExactSynonym "PBD-based Anti-CD352 ADC SGN-CD352A" @default.
- NCIT_C131174 hasExactSynonym "PBD-based Anti-CD352 Antibody-drug Conjugate SGN-CD352A" @default.
- NCIT_C131174 hasExactSynonym "SGN-CD352A" @default.
- NCIT_C131174 inSubset NCIT_C116977 @default.
- NCIT_C131174 inSubset NCIT_C116978 @default.
- NCIT_C131174 inSubset NCIT_C128784 @default.
- NCIT_C131174 inSubset NCIT_C157711 @default.
- NCIT_C131174 inSubset NCIT_C157712 @default.
- NCIT_C131174 inSubset NCIT_C176424 @default.
- NCIT_C131174 inSubset NCIT_C177537 @default.
- NCIT_C131174 inSubset NCIT_C63923 @default.
- NCIT_C131174 type Class @default.
- NCIT_C131174 isDefinedBy ncit.owl @default.
- NCIT_C131174 label "Anti-CD352 Antibody-drug Conjugate SGN-CD352A" @default.
- NCIT_C131174 subClassOf NCIT_C129821 @default.
- NCIT_C131174 subClassOf NCIT_C129823 @default.
- NCIT_C131174 subClassOf NCIT_C131174 @default.
- NCIT_C131174 subClassOf NCIT_C1512 @default.
- NCIT_C131174 subClassOf NCIT_C1908 @default.
- NCIT_C131174 subClassOf NCIT_C1909 @default.
- NCIT_C131174 subClassOf NCIT_C274 @default.
- NCIT_C131174 subClassOf NCIT_C307 @default.
- NCIT_C131174 subClassOf NCIT_C308 @default.