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- NCIT_C131175 IAO_0000115 "An antibody mixture composed of six humanized, immunoglobulin G1 (IgG1) monoclonal antibodies directed against three members of the human epidermal growth factor receptor (EGFR; HER) family: EGFR (HER1; ErbB1), HER2 (ErbB2) and HER3 (ErbB3), with potential antineoplastic activity. Upon administration of anti-EGFR/HER2/HER3 monoclonal antibody mixture Sym013, the six antibodies bind to non-overlapping epitopes on EGFR, HER2 and HER3, which prevents both ligand binding and receptor activation, and induce simultaneous down-modulation of EGFR, HER2 and HER3. This inhibits the activation of HER-dependent signaling pathways and HER-dependent tumor cell proliferation. Overexpression of the HER family plays a key role in many cancers; targeting multiple HER family members simultaneously may increase therapeutic efficacy." @default.
- NCIT_C131175 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131175 NCIT_A7 NCIT_C17068 @default.
- NCIT_C131175 NCIT_A7 NCIT_C17319 @default.
- NCIT_C131175 NCIT_A7 NCIT_C18490 @default.
- NCIT_C131175 NCIT_NHC0 "C131175" @default.
- NCIT_C131175 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C131175 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131175 NCIT_P107 "Anti-EGFR/HER2/HER3 Monoclonal Antibody Mixture Sym013" @default.
- NCIT_C131175 NCIT_P108 "Anti-EGFR/HER2/HER3 Monoclonal Antibody Mixture Sym013" @default.
- NCIT_C131175 NCIT_P208 "CL513501" @default.
- NCIT_C131175 NCIT_P322 "CTRP" @default.
- NCIT_C131175 NCIT_P322 "GDC" @default.
- NCIT_C131175 NCIT_P329 "785503" @default.
- NCIT_C131175 NCIT_P330 "785503" @default.
- NCIT_C131175 NCIT_P375 "Anti-EGFR/HER2/HER3 Monoclonal Antibody Mixture Sym013" @default.
- NCIT_C131175 NCIT_P399 "785503" @default.
- NCIT_C131175 NCIT_R124 NCIT_C17710 @default.
- NCIT_C131175 NCIT_R124 NCIT_C17828 @default.
- NCIT_C131175 NCIT_R124 NCIT_C18219 @default.
- NCIT_C131175 NCIT_R124 NCIT_C19986 @default.
- NCIT_C131175 NCIT_R124 NCIT_C40474 @default.
- NCIT_C131175 normalizedInformationContent "100" @default.
- NCIT_C131175 referenceCount "1" @default.
- NCIT_C131175 hasExactSynonym "Anti-EGFR/HER2/HER3 Monoclonal Antibody Mixture Sym013" @default.
- NCIT_C131175 hasExactSynonym "Pan-HER mAb Mixture Sym013" @default.
- NCIT_C131175 hasExactSynonym "Sym-013" @default.
- NCIT_C131175 hasExactSynonym "Sym013" @default.
- NCIT_C131175 hasExactSynonym "pan-HER Antibody Mixture Sym013" @default.
- NCIT_C131175 inSubset NCIT_C116977 @default.
- NCIT_C131175 inSubset NCIT_C116978 @default.
- NCIT_C131175 inSubset NCIT_C128784 @default.
- NCIT_C131175 inSubset NCIT_C157711 @default.
- NCIT_C131175 inSubset NCIT_C157712 @default.
- NCIT_C131175 inSubset NCIT_C176424 @default.
- NCIT_C131175 inSubset NCIT_C177537 @default.
- NCIT_C131175 type Class @default.
- NCIT_C131175 isDefinedBy ncit.owl @default.
- NCIT_C131175 label "Anti-EGFR/HER2/HER3 Monoclonal Antibody Mixture Sym013" @default.
- NCIT_C131175 subClassOf NCIT_C129821 @default.
- NCIT_C131175 subClassOf NCIT_C129822 @default.
- NCIT_C131175 subClassOf NCIT_C131175 @default.
- NCIT_C131175 subClassOf NCIT_C163758 @default.
- NCIT_C131175 subClassOf NCIT_C1908 @default.
- NCIT_C131175 subClassOf NCIT_C1909 @default.
- NCIT_C131175 subClassOf NCIT_C199383 @default.
- NCIT_C131175 subClassOf NCIT_C199386 @default.
- NCIT_C131175 subClassOf NCIT_C20401 @default.
- NCIT_C131175 subClassOf NCIT_C274 @default.
- NCIT_C131175 subClassOf NCIT_C307 @default.
- NCIT_C131175 subClassOf NCIT_C308 @default.