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- NCIT_C131178 IAO_0000115 "The camsylate salt form of rucaparib, an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes genomic instability and induces cell cycle arrest and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARPs are enzymes activated by single-strand DNA breaks that catalyze the post-translational ADP-ribosylation of nuclear proteins, which induces signaling and the recruitment of other proteins to repair damaged DNA. The PARP-mediated repair pathway plays a key role in DNA repair and is dysregulated in a variety of cancer cell types." @default.
- NCIT_C131178 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131178 NCIT_A7 NCIT_C104720 @default.
- NCIT_C131178 NCIT_A7 NCIT_C147980 @default.
- NCIT_C131178 NCIT_A7 NCIT_C48215 @default.
- NCIT_C131178 NCIT_NHC0 "C131178" @default.
- NCIT_C131178 NCIT_P106 "Organic Chemical" @default.
- NCIT_C131178 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131178 NCIT_P107 "Rucaparib Camsylate" @default.
- NCIT_C131178 NCIT_P108 "Rucaparib Camsylate" @default.
- NCIT_C131178 NCIT_P208 "CL513492" @default.
- NCIT_C131178 NCIT_P210 "1859053-21-6" @default.
- NCIT_C131178 NCIT_P302 "deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer" @default.
- NCIT_C131178 NCIT_P302 "patients with deleterious BRCA mutation (germline and/or somatic)-associated metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor-directed therapy and a taxane-based chemotherapy." @default.
- NCIT_C131178 NCIT_P319 "41AX9SJ8KO" @default.
- NCIT_C131178 NCIT_P322 "CTRP" @default.
- NCIT_C131178 NCIT_P322 "FDA" @default.
- NCIT_C131178 NCIT_P322 "GDC" @default.
- NCIT_C131178 NCIT_P329 "785902" @default.
- NCIT_C131178 NCIT_P330 "785902" @default.
- NCIT_C131178 NCIT_P375 "Rucaparib Camsylate" @default.
- NCIT_C131178 NCIT_P399 "785902" @default.
- NCIT_C131178 NCIT_R146 NCIT_C104101 @default.
- NCIT_C131178 NCIT_R146 NCIT_C16554 @default.
- NCIT_C131178 NCIT_R146 NCIT_C17021 @default.
- NCIT_C131178 NCIT_R146 NCIT_C17210 @default.
- NCIT_C131178 NCIT_R146 NCIT_C17434 @default.
- NCIT_C131178 NCIT_R146 NCIT_C20027 @default.
- NCIT_C131178 NCIT_R146 NCIT_C21170 @default.
- NCIT_C131178 NCIT_R146 NCIT_C26548 @default.
- NCIT_C131178 NCIT_R146 NCIT_C48215 @default.
- NCIT_C131178 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C131178 referenceCount "2" @default.
- NCIT_C131178 hasExactSynonym "8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-pyrrolo(4,3,2-ef)(2)benzazepin-6-one (7,7-dimethyl-2-oxobicyclo(2.2.1)heptan-1-yl)methanesulfonate (1:1)" @default.
- NCIT_C131178 hasExactSynonym "8-Fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonic Acid Salt" @default.
- NCIT_C131178 hasExactSynonym "Bicyclo(2.2.1)heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, Compound with 8-Fluoro-1,3,4,5-tetrahydro-2-(4-((methylamino)methyl)phenyl)-6H-pyrrolo(4,3,2-ef)(2)benzazepin-6-one (1:1)" @default.
- NCIT_C131178 hasExactSynonym "C0-338" @default.
- NCIT_C131178 hasExactSynonym "RUCAPARIB CAMSYLATE" @default.
- NCIT_C131178 hasExactSynonym "Rubraca" @default.
- NCIT_C131178 hasExactSynonym "Rucaparib Camsylate" @default.
- NCIT_C131178 hasExactSynonym "Rucaparib Phosphate" @default.
- NCIT_C131178 inSubset NCIT_C116977 @default.
- NCIT_C131178 inSubset NCIT_C116978 @default.
- NCIT_C131178 inSubset NCIT_C128784 @default.
- NCIT_C131178 inSubset NCIT_C157711 @default.
- NCIT_C131178 inSubset NCIT_C157712 @default.
- NCIT_C131178 inSubset NCIT_C176424 @default.
- NCIT_C131178 inSubset NCIT_C177537 @default.
- NCIT_C131178 inSubset NCIT_C63923 @default.
- NCIT_C131178 type Class @default.
- NCIT_C131178 isDefinedBy ncit.owl @default.
- NCIT_C131178 label "Rucaparib Camsylate" @default.
- NCIT_C131178 subClassOf NCIT_C131178 @default.
- NCIT_C131178 subClassOf NCIT_C163758 @default.
- NCIT_C131178 subClassOf NCIT_C1908 @default.
- NCIT_C131178 subClassOf NCIT_C1909 @default.
- NCIT_C131178 subClassOf NCIT_C274 @default.
- NCIT_C131178 subClassOf NCIT_C471 @default.
- NCIT_C131178 subClassOf NCIT_C62554 @default.