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- NCIT_C131211 IAO_0000115 "A radioconjugate composed of the beta-amyloid binding agent Pittsburgh compound B (PiB), a derivative of the amyloid-binding dye thioflavin T (ThT), that is conjugated to the radioisotope carbon C11, with potential amyloid imaging activity upon positron emission tomography (PET). Upon administration of carbon C 11 PiB, the PiB moiety targets and binds to beta-amyloid plaques in the brain, which can then be detected and analyzed using PET imaging. Increased production and concentration of amyloid beta protein and the deposition of amyloid plaques in the brain are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI)." @default.
- NCIT_C131211 NCIT_NHC0 "C131211" @default.
- NCIT_C131211 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131211 NCIT_P107 "Carbon C 11 Pittsburgh Compound B" @default.
- NCIT_C131211 NCIT_P108 "Carbon C 11 Pittsburgh Compound B" @default.
- NCIT_C131211 NCIT_P208 "CL514003" @default.
- NCIT_C131211 NCIT_P322 "CTRP" @default.
- NCIT_C131211 NCIT_P399 "810805" @default.
- NCIT_C131211 normalizedInformationContent "100" @default.
- NCIT_C131211 referenceCount "1" @default.
- NCIT_C131211 hasExactSynonym "11 Carbon Pittsburgh Compound B" @default.
- NCIT_C131211 hasExactSynonym "11C-PIB" @default.
- NCIT_C131211 hasExactSynonym "11C-PiB" @default.
- NCIT_C131211 hasExactSynonym "C11 Pittsburgh Compound B" @default.
- NCIT_C131211 hasExactSynonym "C11-PiB" @default.
- NCIT_C131211 hasExactSynonym "Carbon C 11 Pittsburgh Compound B" @default.
- NCIT_C131211 hasExactSynonym "[11C]PiB" @default.
- NCIT_C131211 hasExactSynonym "[N-methyl-11C]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole" @default.
- NCIT_C131211 inSubset NCIT_C116977 @default.
- NCIT_C131211 inSubset NCIT_C116978 @default.
- NCIT_C131211 inSubset NCIT_C176424 @default.
- NCIT_C131211 type Class @default.
- NCIT_C131211 isDefinedBy ncit.owl @default.
- NCIT_C131211 label "Carbon C 11 Pittsburgh Compound B" @default.
- NCIT_C131211 subClassOf NCIT_C131211 @default.
- NCIT_C131211 subClassOf NCIT_C1446 @default.
- NCIT_C131211 subClassOf NCIT_C1908 @default.
- NCIT_C131211 subClassOf NCIT_C1909 @default.
- NCIT_C131211 subClassOf NCIT_C2124 @default.