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- NCIT_C131287 IAO_0000115 "A cell-based cancer vaccine composed dendritic cells (DC) that were matured in the presence of a synthetic complex comprised of polyinosinic-polycytidylic acid, poly-L-lysine double-stranded RNA, and carboxymethylcellulose (poly-ICLC), and then pulsed with peptides derived from the tumor-associated antigens (TAAs) cancer/testis antigen NY-ESO-1 and melanoma antigen recognized by T-cells (MART-1/Melan-A), which are linked to the immunostimulant and carrier protein keyhole limpet hemocyanin (KLH), with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, the KLH/NY-ESO-1/MART-1 peptide-pulsed DC vaccine stimulates the immune system to mount an anti-tumor cytotoxic T-lymphocyte (CTL) response against NY-ESO-1/MART-1-expressing tumor cells, which may result in tumor cell lysis. NY-ESO-1 is expressed both in normal testes and on the surfaces of various tumor cells. MART-1 is expressed by melanoma cells. The adjuvant poly-ICLC, a ligand for toll-like receptor-3 (TLR-3), induces the release of cytokines that may help boost the immune response against the TAAs. KLH boosts the immune response against the TAA-expressing tumor cells." @default.
- NCIT_C131287 NCIT_A7 NCIT_C33992 @default.
- NCIT_C131287 NCIT_A7 NCIT_C39286 @default.
- NCIT_C131287 NCIT_NHC0 "C131287" @default.
- NCIT_C131287 NCIT_P106 "Cell" @default.
- NCIT_C131287 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131287 NCIT_P107 "KLH/NY-ESO-1/MART-1 Peptide-pulsed Dendritic Cell Vaccine" @default.
- NCIT_C131287 NCIT_P108 "KLH/NY-ESO-1/MART-1 Peptide-pulsed Dendritic Cell Vaccine" @default.
- NCIT_C131287 NCIT_P208 "CL514432" @default.
- NCIT_C131287 NCIT_P322 "CTRP" @default.
- NCIT_C131287 normalizedInformationContent "100" @default.
- NCIT_C131287 referenceCount "1" @default.
- NCIT_C131287 hasExactSynonym "KLH/NY-ESO-1/MART-1 Peptide-pulsed DC Vaccine" @default.
- NCIT_C131287 hasExactSynonym "KLH/NY-ESO-1/MART-1 Peptide-pulsed Dendritic Cell Vaccine" @default.
- NCIT_C131287 hasExactSynonym "KLH/NY-ESO-1/Melan-A Peptide-pulsed DC Vaccine" @default.
- NCIT_C131287 hasExactSynonym "NY-ESO-1/MART-1 Peptide/KLH-pulsed Dendritic Cell Vaccine" @default.
- NCIT_C131287 inSubset NCIT_C116977 @default.
- NCIT_C131287 inSubset NCIT_C116978 @default.
- NCIT_C131287 inSubset NCIT_C128784 @default.
- NCIT_C131287 type Class @default.
- NCIT_C131287 isDefinedBy ncit.owl @default.
- NCIT_C131287 label "KLH/NY-ESO-1/MART-1 Peptide-pulsed Dendritic Cell Vaccine" @default.
- NCIT_C131287 subClassOf NCIT_C129820 @default.
- NCIT_C131287 subClassOf NCIT_C131287 @default.
- NCIT_C131287 subClassOf NCIT_C1663 @default.
- NCIT_C131287 subClassOf NCIT_C1908 @default.
- NCIT_C131287 subClassOf NCIT_C1909 @default.
- NCIT_C131287 subClassOf NCIT_C274 @default.
- NCIT_C131287 subClassOf NCIT_C28308 @default.
- NCIT_C131287 subClassOf NCIT_C28310 @default.
- NCIT_C131287 subClassOf NCIT_C307 @default.
- NCIT_C131287 subClassOf NCIT_C308 @default.
- NCIT_C131287 subClassOf NCIT_C923 @default.