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- NCIT_C131289 IAO_0000115 "An orally bioavailable fluorinated analog of fucose that is a protein fucosylation inhibitor, with potential antineoplastic and immunomodulating activities. Upon administration, 2-fluorofucose (2-FF) mimics fucose and is converted to guanosine diphosphate (GDP)-2FF, which prevents the formation of the fucosylation substrate GDP-fucose, and the incorporation of fucose into glycoproteins by fucosyltransferase. As fucosylation of glycoproteins plays a key role in many biological processes, such as protein function, receptor binding, cell signaling and cellular adhesion, and is essential for tumor progression, blocking fucosylation decreases tumor cell growth. In addition, blocking fucosylation of monoclonal antibodies generates fucose-deficient antibodies that exert enhanced antibody-dependent cell-mediated cytotoxicity (ADCC)." @default.
- NCIT_C131289 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131289 NCIT_NHC0 "C131289" @default.
- NCIT_C131289 NCIT_P106 "Organic Chemical" @default.
- NCIT_C131289 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131289 NCIT_P107 "2-Fluorofucose" @default.
- NCIT_C131289 NCIT_P108 "2-Fluorofucose" @default.
- NCIT_C131289 NCIT_P208 "CL514470" @default.
- NCIT_C131289 NCIT_P210 "70763-62-1" @default.
- NCIT_C131289 NCIT_P319 "W39886N0ZG" @default.
- NCIT_C131289 NCIT_P322 "CTRP" @default.
- NCIT_C131289 NCIT_P322 "FDA" @default.
- NCIT_C131289 NCIT_P322 "GDC" @default.
- NCIT_C131289 NCIT_P329 "785540" @default.
- NCIT_C131289 NCIT_P330 "785540" @default.
- NCIT_C131289 NCIT_P375 "2-Fluorofucose-containing SGN-2FF" @default.
- NCIT_C131289 NCIT_P399 "785540" @default.
- NCIT_C131289 normalizedInformationContent "100" @default.
- NCIT_C131289 referenceCount "1" @default.
- NCIT_C131289 hasExactSynonym "2-FF Containing SGN-2FF" @default.
- NCIT_C131289 hasExactSynonym "2-FLUOROFUCOSE" @default.
- NCIT_C131289 hasExactSynonym "2-Fluorofucose" @default.
- NCIT_C131289 hasExactSynonym "2FF-containing SGN-2FF" @default.
- NCIT_C131289 hasExactSynonym "SGN-2FF" @default.
- NCIT_C131289 inSubset NCIT_C116977 @default.
- NCIT_C131289 inSubset NCIT_C116978 @default.
- NCIT_C131289 inSubset NCIT_C128784 @default.
- NCIT_C131289 inSubset NCIT_C157711 @default.
- NCIT_C131289 inSubset NCIT_C157712 @default.
- NCIT_C131289 inSubset NCIT_C176424 @default.
- NCIT_C131289 inSubset NCIT_C177537 @default.
- NCIT_C131289 inSubset NCIT_C63923 @default.
- NCIT_C131289 type Class @default.
- NCIT_C131289 isDefinedBy ncit.owl @default.
- NCIT_C131289 label "2-Fluorofucose" @default.
- NCIT_C131289 subClassOf NCIT_C129820 @default.
- NCIT_C131289 subClassOf NCIT_C131289 @default.
- NCIT_C131289 subClassOf NCIT_C1908 @default.
- NCIT_C131289 subClassOf NCIT_C1909 @default.
- NCIT_C131289 subClassOf NCIT_C274 @default.
- NCIT_C131289 subClassOf NCIT_C308 @default.