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- NCIT_C131303 IAO_0000115 "An orally available inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, pulrodemstat binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor (remove hyphen) suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family that is overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival." @default.
- NCIT_C131303 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131303 NCIT_A7 NCIT_C78143 @default.
- NCIT_C131303 NCIT_NHC0 "C131303" @default.
- NCIT_C131303 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131303 NCIT_P107 "Pulrodemstat" @default.
- NCIT_C131303 NCIT_P108 "Pulrodemstat" @default.
- NCIT_C131303 NCIT_P208 "CL514523" @default.
- NCIT_C131303 NCIT_P210 "1821307-10-1" @default.
- NCIT_C131303 NCIT_P319 "W6F4FRQ5QC" @default.
- NCIT_C131303 NCIT_P322 "CTRP" @default.
- NCIT_C131303 NCIT_P322 "FDA" @default.
- NCIT_C131303 NCIT_P322 "GDC" @default.
- NCIT_C131303 NCIT_P329 "785511" @default.
- NCIT_C131303 NCIT_P330 "785511" @default.
- NCIT_C131303 NCIT_P375 "LSD1 Inhibitor CC-90011" @default.
- NCIT_C131303 NCIT_P399 "785511" @default.
- NCIT_C131303 normalizedInformationContent "100" @default.
- NCIT_C131303 referenceCount "1" @default.
- NCIT_C131303 hasExactSynonym "CC 90011" @default.
- NCIT_C131303 hasExactSynonym "CC-90011" @default.
- NCIT_C131303 hasExactSynonym "CC90011" @default.
- NCIT_C131303 hasExactSynonym "LSD1 Inhibitor CC-90011" @default.
- NCIT_C131303 hasExactSynonym "Lysine-specific Demethylase 1 Inhibitor CC-90011" @default.
- NCIT_C131303 hasExactSynonym "PULRODEMSTAT" @default.
- NCIT_C131303 hasExactSynonym "Pulrodemstat" @default.
- NCIT_C131303 inSubset NCIT_C116977 @default.
- NCIT_C131303 inSubset NCIT_C116978 @default.
- NCIT_C131303 inSubset NCIT_C128784 @default.
- NCIT_C131303 inSubset NCIT_C157711 @default.
- NCIT_C131303 inSubset NCIT_C157712 @default.
- NCIT_C131303 inSubset NCIT_C176424 @default.
- NCIT_C131303 inSubset NCIT_C177537 @default.
- NCIT_C131303 inSubset NCIT_C63923 @default.
- NCIT_C131303 type Class @default.
- NCIT_C131303 isDefinedBy ncit.owl @default.
- NCIT_C131303 label "Pulrodemstat" @default.
- NCIT_C131303 subClassOf NCIT_C129824 @default.
- NCIT_C131303 subClassOf NCIT_C129825 @default.
- NCIT_C131303 subClassOf NCIT_C131303 @default.
- NCIT_C131303 subClassOf NCIT_C1908 @default.
- NCIT_C131303 subClassOf NCIT_C1909 @default.
- NCIT_C131303 subClassOf NCIT_C2189 @default.
- NCIT_C131303 subClassOf NCIT_C274 @default.
- NCIT_C131303 subClassOf NCIT_C471 @default.