Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C131333> ?p ?o ?g. }
Showing items 1 to 29 of
29
with 100 items per page.
- NCIT_C131333 IAO_0000115 "A preparation containing plant-derived polyphenolic bioflavonoids composed of multimers (dimers, trimers, or higher order polymers) of the flavan-3-ol-based monomers catechin and epicatechin, which are extracted from sources rich in these chemicals, such as grape seeds, grape skin and pine bark, with potential anti-oxidant, anti-inflammatory, anti-microbial, anti-cancer and protective activities. Upon oral administration of oligomeric procyanidin complex (OPC), the polyphenols exert anti-oxidant activity by scavenging free radicals, which prevents both the formation of reactive oxygen species (ROS), particularly nitrous oxide (NO), and DNA damage. OPC also inhibits chemical-induced lipid peroxidation. In addition, OPC reduces the production advanced glycation end-products (AGE), decreases AGE accumulation in tissues, and inhibits the progression of AGE/receptor for AGE (RAGE)-mediated inflammatory transduction pathways, which inhibits the activation of pro-inflammatory transcriptional regulators and prevents the secretion of pro-inflammatory cytokines/chemokines. This ultimately prevents inflammatory-driven damage to end organs and may reduce inflammation-induced cancer formation and progression. In addition, OPC inhibits the activity of a variety of enzymes, including xanthine oxidase, collagenase, elastase hyaluronidase and beta-glucuronidase." @default.
- NCIT_C131333 NCIT_NHC0 "C131333" @default.
- NCIT_C131333 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131333 NCIT_P107 "Oligomeric Procyanidin Complex" @default.
- NCIT_C131333 NCIT_P108 "Oligomeric Procyanidin Complex" @default.
- NCIT_C131333 NCIT_P208 "CL514533" @default.
- NCIT_C131333 NCIT_P322 "CTRP" @default.
- NCIT_C131333 NCIT_P329 "786083" @default.
- NCIT_C131333 NCIT_P330 "786083" @default.
- NCIT_C131333 NCIT_P399 "786083" @default.
- NCIT_C131333 normalizedInformationContent "100" @default.
- NCIT_C131333 referenceCount "1" @default.
- NCIT_C131333 hasExactSynonym "OPC" @default.
- NCIT_C131333 hasExactSynonym "Oligomeric Flavanols" @default.
- NCIT_C131333 hasExactSynonym "Oligomeric Proanthocyanidins" @default.
- NCIT_C131333 hasExactSynonym "Oligomeric Procyanidin Complex" @default.
- NCIT_C131333 hasExactSynonym "Oligomeric Procyanidolic Complex" @default.
- NCIT_C131333 inSubset NCIT_C116977 @default.
- NCIT_C131333 inSubset NCIT_C116978 @default.
- NCIT_C131333 inSubset NCIT_C128784 @default.
- NCIT_C131333 inSubset NCIT_C176424 @default.
- NCIT_C131333 type Class @default.
- NCIT_C131333 isDefinedBy ncit.owl @default.
- NCIT_C131333 label "Oligomeric Procyanidin Complex" @default.
- NCIT_C131333 subClassOf NCIT_C131333 @default.
- NCIT_C131333 subClassOf NCIT_C1908 @default.
- NCIT_C131333 subClassOf NCIT_C1909 @default.
- NCIT_C131333 subClassOf NCIT_C26170 @default.
- NCIT_C131333 subClassOf NCIT_C275 @default.