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- NCIT_C131497 IAO_0000115 "A radioconjugate containing the epidermal growth factor receptor (EGFR) kinase tracer ODS2004436 labeled with fluorine F 18 for potential tumor imaging using positron emission tomography (PET). Upon administration of fluorine F 18 ODS2004436, the ODS2004436 moiety selectively targets and binds to forms of EGFR that contain activating mutations. This allows the visualization of tumor cells expressing activating EGFR mutations using PET. This agent can also be utilized in the prediction of responsiveness to EGFR tyrosine kinase inhibitors (TKIs) and the selection of patients that respond well to those kinase inhibitors that specifically target forms of EGFR with activating mutations. EGFR-activating mutations play a key role in the development of certain tumors and in tumor resistance to a variety of antineoplastic agents." @default.
- NCIT_C131497 NCIT_NHC0 "C131497" @default.
- NCIT_C131497 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C131497 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131497 NCIT_P108 "Fluorine F 18 ODS2004436" @default.
- NCIT_C131497 NCIT_P208 "CL514285" @default.
- NCIT_C131497 NCIT_P329 "785933" @default.
- NCIT_C131497 NCIT_P330 "785933" @default.
- NCIT_C131497 NCIT_P399 "785933" @default.
- NCIT_C131497 normalizedInformationContent "100" @default.
- NCIT_C131497 referenceCount "1" @default.
- NCIT_C131497 hasExactSynonym "18F-ODS2004436" @default.
- NCIT_C131497 hasExactSynonym "Fluorine F 18 ODS2004436" @default.
- NCIT_C131497 hasExactSynonym "[18F]-ODS2004436" @default.
- NCIT_C131497 inSubset NCIT_C176424 @default.
- NCIT_C131497 type Class @default.
- NCIT_C131497 isDefinedBy ncit.owl @default.
- NCIT_C131497 label "Fluorine F 18 ODS2004436" @default.
- NCIT_C131497 subClassOf NCIT_C131497 @default.
- NCIT_C131497 subClassOf NCIT_C1446 @default.
- NCIT_C131497 subClassOf NCIT_C1908 @default.
- NCIT_C131497 subClassOf NCIT_C1909 @default.
- NCIT_C131497 subClassOf NCIT_C2124 @default.