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- NCIT_C131572 IAO_0000115 "A humanized immunoglobulin (Ig) G1 monoclonal antibody (mAb) against C-X-C chemokine receptor type 4 (CXCR4), with potential antineoplastic activity. Upon administration, anti-CXCR4 mAb PF-06747143 binds to CXCR4, thereby preventing the binding of stromal cell-derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation. This results in decreased proliferation and migration of CXCR4-expressing tumor cells. In addition, PF-06747143 promotes cell death through the induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family, is upregulated in several tumor cell types and plays an important role in cancer cell proliferation, survival, and chemotaxis, and in tumor angiogenesis." @default.
- NCIT_C131572 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131572 NCIT_A7 NCIT_C17789 @default.
- NCIT_C131572 NCIT_NHC0 "C131572" @default.
- NCIT_C131572 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C131572 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131572 NCIT_P107 "Anti-CXCR4 Monoclonal Antibody PF-06747143" @default.
- NCIT_C131572 NCIT_P108 "Anti-CXCR4 Monoclonal Antibody PF-06747143" @default.
- NCIT_C131572 NCIT_P208 "CL514243" @default.
- NCIT_C131572 NCIT_P319 "7TS9C20ZWA" @default.
- NCIT_C131572 NCIT_P322 "CTRP" @default.
- NCIT_C131572 NCIT_P322 "FDA" @default.
- NCIT_C131572 NCIT_P322 "GDC" @default.
- NCIT_C131572 NCIT_P329 "786269" @default.
- NCIT_C131572 NCIT_P330 "786269" @default.
- NCIT_C131572 NCIT_P375 "Anti-CXCR4 Monoclonal Antibody PF-06747143" @default.
- NCIT_C131572 NCIT_P399 "786269" @default.
- NCIT_C131572 NCIT_R124 NCIT_C17710 @default.
- NCIT_C131572 NCIT_R124 NCIT_C17828 @default.
- NCIT_C131572 NCIT_R124 NCIT_C18219 @default.
- NCIT_C131572 NCIT_R124 NCIT_C19986 @default.
- NCIT_C131572 NCIT_R124 NCIT_C40474 @default.
- NCIT_C131572 normalizedInformationContent "100" @default.
- NCIT_C131572 referenceCount "1" @default.
- NCIT_C131572 hasExactSynonym "Anti-CXCR4 IgG1 Antibody PF-06747143" @default.
- NCIT_C131572 hasExactSynonym "Anti-CXCR4 Monoclonal Antibody PF-06747143" @default.
- NCIT_C131572 hasExactSynonym "PF 06747143" @default.
- NCIT_C131572 hasExactSynonym "PF-06747143" @default.
- NCIT_C131572 inSubset NCIT_C116977 @default.
- NCIT_C131572 inSubset NCIT_C116978 @default.
- NCIT_C131572 inSubset NCIT_C128784 @default.
- NCIT_C131572 inSubset NCIT_C157711 @default.
- NCIT_C131572 inSubset NCIT_C157712 @default.
- NCIT_C131572 inSubset NCIT_C176424 @default.
- NCIT_C131572 inSubset NCIT_C177537 @default.
- NCIT_C131572 inSubset NCIT_C63923 @default.
- NCIT_C131572 type Class @default.
- NCIT_C131572 isDefinedBy ncit.owl @default.
- NCIT_C131572 label "Anti-CXCR4 Monoclonal Antibody PF-06747143" @default.
- NCIT_C131572 subClassOf NCIT_C129821 @default.
- NCIT_C131572 subClassOf NCIT_C129822 @default.
- NCIT_C131572 subClassOf NCIT_C131572 @default.
- NCIT_C131572 subClassOf NCIT_C1908 @default.
- NCIT_C131572 subClassOf NCIT_C1909 @default.
- NCIT_C131572 subClassOf NCIT_C20401 @default.
- NCIT_C131572 subClassOf NCIT_C274 @default.
- NCIT_C131572 subClassOf NCIT_C307 @default.
- NCIT_C131572 subClassOf NCIT_C308 @default.