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- NCIT_C131580 IAO_0000115 "A recombinant, replication competent form of the oncolytic RNA virus vesicular stomatitis virus (VSV), based on the Indiana strain of VSV, that is genetically engineered to express the genes for the human cytokine interferon beta (IFNbeta) and the human thyroidal sodium-iodide symporter (NIS), with potential oncolytic and imaging activities. Upon intravenous administration, VSV-hIFNbeta-NIS is preferentially taken up by tumor cells, resulting in tumor cell infection, viral replication and a direct virus-mediated cytolytic effect against the infected tumor cells. IFN-mediated signaling is defective in tumor cells and tumor cells are unable to exert an anti-viral response against VSV. As normal, healthy cells secrete and respond normally to IFNbeta and are able to activate IFN-mediated anti-viral pathways, the expressed IFNbeta from the VSV-infected tumor cells helps protect normal cells from VSV infection. Upon subsequent administration of certain isotope-containing imaging agents, NIS expression by the infected tumor cells allows visualization and tracking of VSV biodistribution, and analysis and quantification of VSV-infected tumor cells by positron emission tomography (PET). Also, upon subsequent administration of the radioisotope iodine I 131 (I131), I131 can be taken up by NIS and allows for a cytotoxic dose of radiation to accumulate in the NIS-expressing VSV-infected tumor cells, which also leads to tumor cell death." @default.
- NCIT_C131580 NCIT_A32 NCIT_C1909 @default.
- NCIT_C131580 NCIT_NHC0 "C131580" @default.
- NCIT_C131580 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131580 NCIT_P107 "Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter" @default.
- NCIT_C131580 NCIT_P108 "Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter" @default.
- NCIT_C131580 NCIT_P208 "CL514461" @default.
- NCIT_C131580 NCIT_P322 "CTRP" @default.
- NCIT_C131580 NCIT_P322 "GDC" @default.
- NCIT_C131580 NCIT_P329 "788964" @default.
- NCIT_C131580 NCIT_P330 "788964" @default.
- NCIT_C131580 NCIT_P375 "Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter" @default.
- NCIT_C131580 NCIT_P399 "788964" @default.
- NCIT_C131580 normalizedInformationContent "100" @default.
- NCIT_C131580 referenceCount "1" @default.
- NCIT_C131580 hasExactSynonym "Oncolytic VSV-hIFNbeta-NIS" @default.
- NCIT_C131580 hasExactSynonym "Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter" @default.
- NCIT_C131580 hasExactSynonym "VSV-expressing hIFNb and NIS" @default.
- NCIT_C131580 hasExactSynonym "VSV-hIFNb-NIS" @default.
- NCIT_C131580 hasExactSynonym "VSV-hIFNbeta-NIS" @default.
- NCIT_C131580 hasExactSynonym "VV1" @default.
- NCIT_C131580 hasExactSynonym "Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter" @default.
- NCIT_C131580 hasExactSynonym "Voyager-V1" @default.
- NCIT_C131580 inSubset NCIT_C116977 @default.
- NCIT_C131580 inSubset NCIT_C116978 @default.
- NCIT_C131580 inSubset NCIT_C128784 @default.
- NCIT_C131580 inSubset NCIT_C157711 @default.
- NCIT_C131580 inSubset NCIT_C157712 @default.
- NCIT_C131580 inSubset NCIT_C176424 @default.
- NCIT_C131580 inSubset NCIT_C177537 @default.
- NCIT_C131580 type Class @default.
- NCIT_C131580 isDefinedBy ncit.owl @default.
- NCIT_C131580 label "Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter" @default.
- NCIT_C131580 subClassOf NCIT_C129821 @default.
- NCIT_C131580 subClassOf NCIT_C131580 @default.
- NCIT_C131580 subClassOf NCIT_C1908 @default.
- NCIT_C131580 subClassOf NCIT_C1909 @default.
- NCIT_C131580 subClassOf NCIT_C274 @default.
- NCIT_C131580 subClassOf NCIT_C307 @default.
- NCIT_C131580 subClassOf NCIT_C717 @default.