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- NCIT_C1316 IAO_0000115 "An antagonist of the neurotransmitter dopamine with potential antineoplastic activity. 6-Hydroxydopamine (6-HOD) can be taken up by selective adrenergic terminals, thereby causing acute degeneration of adrenergic terminals that leads to depletion of norepinephrine, and of dopamine in the dopamine-sensitive sites. This agent is auto-oxidated at physiological pH that leads to the formation of reactive free radicals, thereby leading to cytotoxicity in neural cells. 6-Hydroxydopamine is often used to induce CNS and sympathetic neural lesions that model aging and various nervous disorders in animal systems." @default.
- NCIT_C1316 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1316 NCIT_NHC0 "C1316" @default.
- NCIT_C1316 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1316 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1316 NCIT_P108 "Oxidopamine" @default.
- NCIT_C1316 NCIT_P171 "2511086" @default.
- NCIT_C1316 NCIT_P175 "233898" @default.
- NCIT_C1316 NCIT_P207 "C0085196" @default.
- NCIT_C1316 NCIT_P210 "1199-18-4" @default.
- NCIT_C1316 NCIT_P319 "8HW4YBZ748" @default.
- NCIT_C1316 NCIT_P322 "FDA" @default.
- NCIT_C1316 NCIT_P322 "GDC" @default.
- NCIT_C1316 NCIT_P329 "41295" @default.
- NCIT_C1316 NCIT_P330 "41295" @default.
- NCIT_C1316 NCIT_P350 "C8H11NO3" @default.
- NCIT_C1316 NCIT_P366 "_6-Hydroxydopamine" @default.
- NCIT_C1316 NCIT_P375 "Oxidopamine" @default.
- NCIT_C1316 NCIT_P399 "41295" @default.
- NCIT_C1316 normalizedInformationContent "100" @default.
- NCIT_C1316 referenceCount "1" @default.
- NCIT_C1316 hasExactSynonym "2,4,5-Trihydroxyphenethylamine" @default.
- NCIT_C1316 hasExactSynonym "5-(2-Aminoethyl)-1,2,4-benzenetriol" @default.
- NCIT_C1316 hasExactSynonym "6-Hydroxydopamine" @default.
- NCIT_C1316 hasExactSynonym "6-OHDA" @default.
- NCIT_C1316 hasExactSynonym "OXIDOPAMINE" @default.
- NCIT_C1316 hasExactSynonym "Oxidopamine" @default.
- NCIT_C1316 inSubset NCIT_C128784 @default.
- NCIT_C1316 inSubset NCIT_C157711 @default.
- NCIT_C1316 inSubset NCIT_C157712 @default.
- NCIT_C1316 inSubset NCIT_C176424 @default.
- NCIT_C1316 inSubset NCIT_C177537 @default.
- NCIT_C1316 inSubset NCIT_C63923 @default.
- NCIT_C1316 type Class @default.
- NCIT_C1316 isDefinedBy ncit.owl @default.
- NCIT_C1316 label "Oxidopamine" @default.
- NCIT_C1316 subClassOf NCIT_C1316 @default.
- NCIT_C1316 subClassOf NCIT_C1908 @default.
- NCIT_C1316 subClassOf NCIT_C1909 @default.
- NCIT_C1316 subClassOf NCIT_C66883 @default.
- NCIT_C1316 subClassOf NCIT_C78272 @default.