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- NCIT_C131874 IAO_0000115 "An orally bioavailable androgen receptor (AR) antagonist, with potential antineoplastic activity. Upon oral administration, AR antagonist TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells." @default.
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- NCIT_C131874 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C131874 NCIT_P107 "Androgen Receptor Antagonist TRC253" @default.
- NCIT_C131874 NCIT_P108 "Androgen Receptor Antagonist TRC253" @default.
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- NCIT_C131874 NCIT_P375 "Androgen Receptor Antagonist TRC253" @default.
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- NCIT_C131874 referenceCount "1" @default.
- NCIT_C131874 hasExactSynonym "AR Antagonist TRC253" @default.
- NCIT_C131874 hasExactSynonym "Androgen Receptor Antagonist TRC253" @default.
- NCIT_C131874 hasExactSynonym "JNJ 63576253" @default.
- NCIT_C131874 hasExactSynonym "JNJ-63576253" @default.
- NCIT_C131874 hasExactSynonym "JNJ63576253" @default.
- NCIT_C131874 hasExactSynonym "TRC 253" @default.
- NCIT_C131874 hasExactSynonym "TRC-253" @default.
- NCIT_C131874 hasExactSynonym "TRC253" @default.
- NCIT_C131874 inSubset NCIT_C116977 @default.
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- NCIT_C131874 type Class @default.
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- NCIT_C131874 label "Androgen Receptor Antagonist TRC253" @default.
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